FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Psn, spdo
FlyBase ID
FBig0000105339
Interaction Network
Interactions Browser links
Psn network
spdo network
Reported Interactions
FBrf0221478-1.coIP.WB
Reference
Upadhyay et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Psn 

Presenilin

bait

Myc tag

spdo 

Sanpodo

prey

FLAG tag

spdo 
spdo 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
spdo 
amino terminal cytoplasmic region
sufficient binding region
aa 100-424
spdo 
N-terminal region
necessary binding region
aa 100-125
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Upadhyay et al., 2013)

The interaction of spdo with Psn was detected only when all four γ-secretase subunits were coexpressed.

(Upadhyay et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)