FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Diap1, Dcp-1
FlyBase ID
FBig0000106974
Interaction Network
Interactions Browser links
Diap1 network
Dcp-1 network
Reported Interactions
FBrf0184187-2.PD.WB
Reference
Tenev et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Diap1 

DIAP1

bait

GST tag

Diap1 
Diap1 
Diap1 
Dcp-1 

DCP-1

prey

V5 tag

Dcp-1 
Dcp-1 
Dcp-1 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Diap1 
N-terminal region
sufficient binding region
aa 1-146

coordinates relative to Diap1-PA

Diap1 
N-terminal region residue P55
mutation disrupting interaction
aa 55

P55L, coordinates relative to Diap1-PA

Diap1 
N-terminal region residue C80
mutation disrupting interaction
aa 80

C80G, coordinates relative to Diap1-PA

Dcp-1 
IBM motif
necessary binding region
AKG
Dcp-1 
IBM motif residue 34
mutation disrupting interaction
aa 34

A34V, coordinates relative to Dcp-1-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from transfected cell extract.

(Tenev et al., 2005)
FBrf0192581-3.coIP.WB
Reference
Leulier et al., 2006
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Diap1 

DIAP1

bait

TAP tag

Dcp-1 

DCP-1

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of 293T cell line; bait produced from transfected construct; prey produced from transfected construct.

(Leulier et al., 2006)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)