FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
HP1b, HP1c
FlyBase ID
FBig0000109806
Interaction Network
Interactions Browser links
HP1b network
HP1c network
Reported Interactions
FBrf0231167-12.CS.WB
Reference
Kessler et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
HP1c 

HP1c

neutral component
HP1c 

HP1c

neutral component
HP1c 

HP1c

neutral component
HP1b 

HP1b

neutral component
HP1b 

HP1b

neutral component
HP1b 

HP1b

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; proteins produced from endogenous genes.

(Kessler et al., 2015)
FBrf0231167-18.coIP.WB
Reference
Kessler et al., 2015
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
HP1c 

HP1c

neutral component
HP1c 

HP1c

neutral component
HP1c 

HP1c

neutral component
HP1b 

HP1b

neutral component
HP1b 

HP1b

neutral component
HP1b 

HP1b

neutral component
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; proteins produced from endogenous genes.

(Kessler et al., 2015)
FBrf0241416-10.PD.WB
Reference
Lee et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
HP1b 

HP1b

bait

FLAG tag

HP1c 

HP1c

prey

GST tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in baculovirus and Sf21 cell system; prey produced as a recombinant fusion protein in bacterial system.

(Lee et al., 2019)
FBrf0241416-12.PD.WB
Reference
Lee et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
HP1c 

HP1c

bait

FLAG tag

HP1b 

HP1b

prey

GST tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in baculovirus and Sf21 cell system; prey produced as a recombinant fusion protein in bacterial system.

(Lee et al., 2019)
FBrf0241416-3.coIP.WB
Reference
Lee et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
HP1b 

HP1b

bait
HP1c 

HP1c

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was nuclear extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Lee et al., 2019)
FBrf0241416-4.coIP.WB
Reference
Lee et al., 2019
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
HP1c 

HP1c

bait
HP1b 

HP1b

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was nuclear extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Lee et al., 2019)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)