FlyBase Gene Report: Dmel\HP1c

General Information

Symbol

Dmel\HP1c

Species

D. melanogaster

Name

Heterochromatin Protein 1c

Annotation Symbol

CG6990

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039019

Gene Model Status

Current

Stock Availability

10 publicly available

Gene Summary

Heterochromatin Protein 1c (HP1c) encodes a chromatin binding protein that is involved in telomere capping and transcription regulation and interacts with the zinc-finger proteins encoded by woc and row. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

HP1

Key Links

Genomic Location

Cytogenetic map

94C4-94C4

Sequence location

3R:22,745,620..22,746,605 [+]

Recombination map

3-76

RefSeq locus

NT_033777 REGION:22745620..22746605

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from direct assay

(Doheny et al., 2008)

enables histone H3K9me2/3 reader activity

inferred from direct assay

(Font-Burgada et al., 2008)

enables histone reader activity

inferred from direct assay

(Doheny et al., 2008)

enables protein binding

inferred from physical interaction with FLYBASE:woc; FB:FBgn0010328

(Font-Burgada et al., 2008)

inferred from physical interaction with FLYBASE:row; FB:FBgn0033998

(Abel et al., 2009, Font-Burgada et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables chromatin binding

inferred from biological aspect of ancestor with PANTHER:PTN000517042

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in positive regulation of transcription by RNA polymerase II

inferred from mutant phenotype

(Font-Burgada et al., 2008)

involved_in subtelomeric heterochromatin formation

inferred from mutant phenotype

(Doheny et al., 2008)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in heterochromatin formation

inferred from biological aspect of ancestor with PANTHER:PTN000517042

(GO Reference Genome Project, 2011-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in euchromatin

inferred from direct assay

(Font-Burgada et al., 2008)

located_in nucleus

inferred from direct assay

(Font-Burgada et al., 2008)

located_in polytene chromosome interband

inferred from direct assay

(Abel et al., 2009, Font-Burgada et al., 2008)

part_of protein-containing complex

inferred from direct assay

(Abel et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in nucleus

inferred from electronic annotation with InterPro:IPR008251

(InterPro Project Members, 2004-)

is_active_in pericentric heterochromatin

inferred from biological aspect of ancestor with PANTHER:PTN000517042

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

HETEROCHROMATIN PROTEIN 1 FAMILY

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

HETEROCHROMATIN PROTEIN 1 FAMILY -: Heterochromatin Protein 1 (HP1, Su(var)205) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin. Members of the HP1 family are characterised by the presence of an N-terminal chromodomain and a C-terminal chromoshadow domain. In addition to heterochromatin packaging and silencing, HP1 proteins have diverse roles in the nucleus, including the regulation of euchromatic genes. (Adapted from FBrf0193304).

Summary (Interactive Fly)

HP1 family member - mchromatin interactor and organizer - physically interacts with DNA-binding zinc-finger transcription factors Without children and Relative-of-WOC to act as a transcriptional activator

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\HP1c for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VCU6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.53

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

HP1c-RA

FBtr0084309

NM_142836

986

237

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

HP1c-PA

FBpp0083702

26.7

237

4.70

Q9VCU6

NP_651093

AAF56059

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VCU6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HP1c using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

HP1c_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

4.07

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | faint | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 12

central brain primordium

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

organism

(Levine et al., 2012)

testis

(Levine et al., 2012)

adult stage | female

organism

(Levine et al., 2012)

ovary

(Levine et al., 2012)

adult stage

adult head

(Levine et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in euchromatin

inferred from direct assay

(Font-Burgada et al., 2008)

located_in nucleus

inferred from direct assay

(Font-Burgada et al., 2008)

located_in polytene chromosome interband

inferred from direct assay

(Abel et al., 2009, Font-Burgada et al., 2008)

part_of protein-containing complex

inferred from direct assay

(Abel et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\HP1c in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\HP1c

View exonic expression by tissue for Dmel\HP1c

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039019

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42696/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039019

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039019

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039019

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6990

Flygut - An atlas of the Drosophila adult midgut

FBgn0039019

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\HP1c

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of HP1c

Transgenic constructs containing regulatory region of HP1c

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6192

(Ryder, 2004.4.26)

Inferred from location ( 3 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Act5C.PI

HP1c^KK112389

viable

HP1c^f04929

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

HP1c^GD12098

viable, with Scer\GAL4^pnr-MD237

Sterility

Allele

fertile

HP1c^f04929

Other Phenotypes

Allele

visible | adult stage, with Scer\GAL4^en.PU

HP1c^KK112389

visible | adult stage, with Scer\GAL4^nub.PK

HP1c^KK112389

Phenotype manifest in

Allele

wing, with Scer\GAL4^en.PU

HP1c^KK112389

wing, with Scer\GAL4^nub.PK

HP1c^KK112389

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (19)

Hsap\CBX3

8 of 14

Yes

7 of 14

7 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Cbx3

8 of 14

Yes

7 of 14

7 of 14

6 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (15)

Mmus\Cbx1

7 of 14

Yes

Mmus\Cbx3

7 of 14

Yes

Mmus\Cbx5

7 of 14

Yes

Mmus\Cbx7

3 of 14

Mmus\Mphosph8

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (19)

Xtro\cbx1

6 of 13

Yes

Xtro\cbx3

6 of 13

Yes

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\suv39h2

1 of 13

Xtro\syngr2

1 of 13

Xtro\ucn3

1 of 13

Yes

Danio rerio (Zebrafish) (19)

Drer\cbx1a

8 of 14

Yes

Drer\cbx1b

8 of 14

Yes

7 of 14

7 of 14

5 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (13)

Cele\hpl-1

10 of 14

Yes

Cele\cec-1

5 of 14

Yes

Cele\cec-3

4 of 14

Yes

4 of 14

3 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\set-31

1 of 14

Yes

Cele\W05F2.8

1 of 14

Anopheles gambiae (African malaria mosquito) (4)

Agam\AgaP_AGAP004723

5 of 12

Yes

Agam\AgaP_AGAP009444

5 of 12

Yes

Agam\AgaP_AGAP003597

1 of 12

Agam\AgaP_AGAP012013

1 of 12

Arabidopsis thaliana (thale-cress) (3)

Atha\TFL2

4 of 13

Yes

Atha\CMT1

1 of 13

Yes

Atha\PKL

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\NEW1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\chp2

5 of 12

Yes

Spom\chp1

4 of 12

Yes

Spom\swi6

4 of 12

Yes

Spom\clr4

1 of 12

Spom\elf1

1 of 12

Spom\hrp3

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:HP1c. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (13)

HP1b

10 of 13

Su(var)205

10 of 13

HP1e

5 of 13

HP6

5 of 13

rhi

5 of 13

CG8289

4 of 13

Oxp

4 of 13

3 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

8 of 14

7 of 14

7 of 14

3 of 14

MPHOSPH8; M-phase phosphoprotein 8

3 of 14

611626

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

HP1c

pull down, anti tag western blot

(Lee et al., 2019)

HP1c - Blos1

two hybrid array

(Shokri et al., 2019)

HP1c - CG5565

experimental knowledge based

(Guruharsha et al., 2011)

HP1c - G9a

pull down, anti tag western blot

(Lee et al., 2019)

HP1c - HP1b

pull down, anti tag western blot, anti bait coimmunoprecipitation, western blot, cosedimentation

(Lee et al., 2019, Kessler et al., 2015)

HP1c - His3

fluorescence polarization spectroscopy, predetermined participant, far western blotting, western blot, pull down, anti tag western blot

(Lee et al., 2019, Kwon et al., 2010, Font-Burgada et al., 2008)

HP1c - Ndc80

anti tag coimmunoprecipitation, peptide massfingerprinting

(Przewloka et al., 2007)

HP1c - Polr2A

anti tag coimmunoprecipitation, western blot, pull down, anti tag western blot

(Lee et al., 2019, Kwon et al., 2010)

HP1c - Sox21b

two hybrid array

(Shokri et al., 2019)

HP1c - Ssrp

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot, anti bait coimmunoprecipitation, tandem affinity purification, multidimensional protein identification technology

(Lee et al., 2019, Kwon et al., 2010)

HP1c - Su(H)

anti tag coimmunoprecipitation, western blot, two hybrid, anti tag western blot

(Sun et al., 2021)

HP1c - Su(var)205

pull down, western blot, anti tag western blot

(Lee et al., 2019, Kwon et al., 2010)

HP1c - Su(var)3-9

pull down, anti tag western blot

(Lee et al., 2019)

HP1c - Tctp

anti bait coimmunoprecipitation

(Ryu et al., 2014)

HP1c - Ubqn

cosedimentation, western blot, anti bait coimmunoprecipitation

(Kessler et al., 2015)

HP1c - dre4

tandem affinity purification, multidimensional protein identification technology, western blot

(Kwon et al., 2010)

HP1c - egg

pull down, anti tag western blot

(Lee et al., 2019)

HP1c - row

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry, cosedimentation, pull down, autoradiography, experimental knowledge based

(Herman et al., 2022, Kessler et al., 2015, Guruharsha et al., 2011, Abel et al., 2009, Font-Burgada et al., 2008)

HP1c - woc

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, Identification by mass spectrometry

(Kessler et al., 2015, Abel et al., 2009, Font-Burgada et al., 2008)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

dom

enhanceable

HP1c

(Ellis et al., 2015)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0039019

MIST (protein-protein) - An integrated Molecular Interaction Database

42696

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Polycomb repressive complex

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-76

Cytogenetic map

94C4-94C4

Sequence location

3R:22,745,620..22,746,605 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94C4-94C4

Limits computationally determined from genome sequence between P{lacW}Gclm^L0580 and P{EP}hh^EP3521

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-76

(FlyBase, 2016)

3-78.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18819

w¹¹¹⁸; PBac{WH}HP1c^f04929

31339

y¹ v¹; P{TRiP.JF01297}attP2

33962

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00919}attP2

NIG-Fly

6990R-1

P{NIG.6990R}1

6990R-3

P{NIG.6990R}3

HMS00919

y¹ sc^* v¹ sev²¹; P{TRiP.HMS00919}attP2

VDRC

v104893

P{KK112389}VIE-260B

v50520

w¹¹¹⁸; P{GD17526}v50520

v318593

PBac{fTRG00541.sfGFP-TVPTBF}VK00033

v341528

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00601}attP40/CyO-GFP

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (74)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD23881

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039019

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039019

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lee et al., 2019, Kessler et al., 2015, Ryu et al., 2014, Lee et al., 2013, Riddle et al., 2011, Font-Burgada et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : Stable S2 cell lines expressing HP1c tagged with Tag:FLAG were established.
(Abel et al., 2009)

Other Comments

DNA-protein interactions: genome-wide binding profile assayed for HP1c protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

(Filion et al., 2010)

Relationship to Other Genes

Source for database merge of

Additional comments

The HP1c gene may have been derived from the Su(var)205 gene by retroposition.

(Pan and Zhang, 2009)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CG6990

(Baumgartner et al., 2022, Levine et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Ni et al., 2008, Przewloka et al., 2007)

HP1

(Peterson et al., 2021, Vidaurre and Chen, 2021, Adashev et al., 2020, Halim et al., 2020, Delandre and Marshall, 2019, Wood et al., 2010, Schulze et al., 2009)

HP1C

(Beck and Llopart, 2015, Ho et al., 2014, Levine and Malik, 2013, Ross et al., 2013, Levine et al., 2012, Levine et al., 2012, van Steensel et al., 2010)

HP1c

(Durmaz Mitchell et al., 2025, Spradling, 2024, Zhimulev et al., 2024, Yheskel et al., 2023, Baumgartner et al., 2022, Herman et al., 2022, McCarthy et al., 2022, Richards et al., 2022, Casale et al., 2021, Li et al., 2021, Schoelz et al., 2021, Sun et al., 2021, Di Mauro et al., 2020, Meyer-Nava et al., 2020, Lee et al., 2019, Shokri et al., 2019, Sarov et al., 2016, Schwartz et al., 2016, Dietz et al., 2015, Ellis et al., 2015, Comoglio and Paro, 2014, dos Santos, 2014, Raffa et al., 2013, Antao et al., 2012, Feller et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Sakoparnig et al., 2012, Demakov et al., 2011, Handler et al., 2011, Kharchenko et al., 2011, Kwon and Workman, 2011, Kwon and Workman, 2011, Filion et al., 2010, Kwon et al., 2010, Abel et al., 2009, Doheny et al., 2008, Lin et al., 2008, Brower-Toland et al., 2007, Przewloka et al., 2007, Lomberk et al., 2006, Moorman et al., 2006, Moorman et al., 2006, Vermaak et al., 2005, Li et al., 2002)

Hp1c

(Wolfe et al., 2021, Kim et al., 2015, Doheny et al., 2008, Mason et al., 2004)

hp1c

(Kessler et al., 2015, Lavrenov et al., 2014, Font-Burgada et al., 2008)

Name Synonyms

HP1c

Heterochromatin Protein 1c

(Comoglio and Paro, 2014)

Heterochromatin protein 1c

(Moorman et al., 2006)

heterochromatin protein 1c

(Feller et al., 2012)

Secondary FlyBase IDs

Datasets (4)

Study focus (4)

Experimental Role

Project

Project Type

Title

transgene_used

FBGSE22069

genome binding

Protein profiling reveals five principal chromatin types in Drosophila cells.

bait_protein

modENCODE_chromatin_proteins_cells

genome binding

Genome-wide localization of chromosomal proteins in cell lines by ChIP-chip and ChIP-Seq.

allele_used

modENCODE_chromatin_proteins_flies

genome binding

Genome-wide localization of chromosomal proteins in fly tissues by ChIP-chip and ChIP-Seq.

allele_used

modENCODE_chromatin_histones_flies

genome binding

Genome-wide localization of histones and their modifications in fly tissues by ChIP-chip and ChIP-Seq.

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42696

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VCU6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VCU6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VCU6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039019

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42696/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039019

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039019

FlyMine - An integrated database for Drosophila genomics

FBgn0039019

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6990

MARRVEL_MODEL - MARRVEL (model organism gene)

42696

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039019

DroID - A comprehensive database of gene and protein interactions.

FBgn0039019

DRSC - Results frm RNAi screens

FBgn0039019

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

HP1c_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039019

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039019

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6990

Flygut - An atlas of the Drosophila adult midgut

FBgn0039019

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Polycomb repressive complex

MIST (protein-protein) - An integrated Molecular Interaction Database

42696

References (110)

The following external sites may use different assemblies or annotations than FlyBase.

4.07

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