FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
gro, Optix
FlyBase ID
FBig0000110611
Interaction Network
Interactions Browser links
gro network
Optix network
Reported Interactions
FBrf0190234-5.Y2H
Reference
Kenyon et al., 2005
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Optix 

Optix

bait

fused to Gal4 DNA binding domain

Optix 
gro 

Gro

prey

fused to GAL4 activation domain

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Optix 
SD and HD domains
sufficient binding region
aa 37-150 and aa 161-212
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was yeast cell line; bait produced as transgenic fusion protein; prey produced as transgenic fusion protein (prey from embryo cDNA expression library).

(Kenyon et al., 2005)

Two-hybrid system: yeast Gal4-BD/GAL4-AD.

(Kenyon et al., 2005)
FBrf0217457-3.coIP.WB
Reference
Anderson et al., 2012
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
gro 

gro

bait

HA tag

Optix 

Optix

prey

Myc tag

Optix 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Optix 
SIX interaction domain
necessary binding region
unspecified
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of Kc167 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Anderson et al., 2012)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)