FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Hsap\TARDBP, CG5445
FlyBase ID
FBig0000116337
Interaction Network
Interactions Browser links
Hsap\TARDBP network
CG5445 network
Reported Interactions
FBrf0237791-1.coIP.WB
Reference
Uechi et al., 2018
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Hsap\TARDBP 

TDP-43

bait

FLAG tag

CG5445 

CG5445

prey

Venus tag

CG5445 
CG5445 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
CG5445 
UBA domain
sufficient binding region
aa 131-170
CG5445 
FW domain
sufficient binding region
aa 181-266
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction was detected using ALS-linked M337V mutant form of Hsap\TARDBP.

(Uechi et al., 2018)

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Uechi et al., 2018)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)