FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
zip, l(2)gl
FlyBase ID
FBig0000120822
Interaction Network
Interactions Browser links
zip network
l(2)gl network
Reported Interactions
FBrf0183828-1.coIP.WB
Reference
Betschinger et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
l(2)gl 

Lgl

bait
zip 

Myosin II

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Betschinger et al., 2005)
FBrf0183828-2.coIP.WB
Reference
Betschinger et al., 2005
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
zip 

Myosin II

bait

GFP tag

l(2)gl 

Lgl

prey

MYC tag

l(2)gl 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
l(2)gl 
central Low Complexity Region and C terminus
sufficient binding region
aa 647-1161

coordinates relative to l(2)gl-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Betschinger et al., 2005)

When the N terminal region of l(2)gl is included in the coIP, zip binding to the C terminus of l(2)gl is lessened.

(Betschinger et al., 2005)
External Crossreferences and Linkouts ( 0 )
References (1)