FB2026_03 , released September 17, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
physical association
Interacting Genes
β-Spec, Hsap\SNCA
FlyBase ID
FBig0000122009
Interaction Network
Interactions Browser links
β-Spec network
Hsap\SNCA network
Reported Interactions
FBrf0255963-1.PD.WB
Reference
Maor et al., 2023
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
β-Spec 

β-Spec

bait

His tag

β-Spec 
Hsap\SNCA 

αsynuclein

prey

GST tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
β-Spec 
spectrin repeat 15
necessary binding region
aa 1807-1909
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

The 15th spectrin repeat of β-Spec was replaced with the 12th spectrin repeat of α-Spec.

(Maor et al., 2023)

Interaction in vitro; bait and prey produced as recombinant fusion proteins in bacterial system.

(Maor et al., 2023)
FBrf0255963-2.PD.WB
Reference
Maor et al., 2023
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hsap\SNCA 

αsynuclein

bait

GST tag

β-Spec 

β-Spec

prey

His tag

β-Spec 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
β-Spec 
spectrin repeat 15
necessary binding region
aa 1807-1909
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

The 15th spectrin repeat of β-Spec was replaced with the 12th spectrin repeat of α-Spec.

(Maor et al., 2023)

Interaction in vitro; bait and prey produced as recombinant fusion proteins in bacterial system.

(Maor et al., 2023)
FBrf0255963-3.coIP.WB
Reference
Maor et al., 2023
Description
physical association
Assay
Collection
Source/Stage
adult head / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hsap\SNCA 

αsynuclein

bait
β-Spec 

β-Spec

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult heads of transgenic fly line; bait produced from transgenic construct; prey produced from endogenous gene.

(Maor et al., 2023)
External Crossreferences and Linkouts ( 0 )
References (1)