FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Sting, imd
FlyBase ID
FBig0000123450
Interaction Network
Interactions Browser links
Sting network
imd network
Reported Interactions
FBrf0260102-2.coIP.WB
Reference
Wang et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
Sting 

STING

bait

HA tag

Sting 
imd 

IMD

prey

Myc tag

imd 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Sting 
cryptic RIP homotypic interaction (cRHIM1) motif
necessary binding region
aa 188-191

VTFG deletion; coordinates relative to Sting-PB

imd 
cryptic RIP homotypic interaction domain
necessary binding region
aa 88-91

LFHG deltion; coordinates relative to imd-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Wang et al., 2024)
FBrf0260102-3.PD.WB
Reference
Wang et al., 2024
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
imd 

IMD

bait

GST tag

imd 
imd 
Sting 

STING

prey

His tag

Sting 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Sting 
cryptic RIP homotypic interaction (cRHIM1) motif
mutation decreasing interaction
aa 188-191

VTFG deletion; coordinates relative to Sting-PB

imd 
cryptic RIP homotypic interaction motif
mutation disrupting interaction
aa 88-91

LFHG deltion; coordinates relative to imd-PA

imd 
death domain
mutation decreasing interaction
aa 178-263

deletion; coordinates relative to imd-PA

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait and prey produced as recombinant fusion proteins in bacterial system.

(Wang et al., 2024)
External Crossreferences and Linkouts ( 0 )
References (1)