FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Hsap\TARDBP, Hsc70-4
FlyBase ID
FBig0000123498
Interaction Network
Interactions Browser links
Hsap\TARDBP network
Hsc70-4 network
Reported Interactions
FBrf0236825-1.coIP.WB
Reference
Coyne et al., 2017
Description
physical association
Assay
Collection
Source/Stage
motor neuron / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hsap\TARDBP 

TDP-43

bait

YFP tag

Hsap\TARDBP 
Hsc70-4 

Hsc70-4

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Hsap\TARDBP 
interaction domain residue 298
mutation increasing interaction
aa 298

G298S

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adults of transgenic fly line expressing Hsap\TARDBP in motor neurons; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Coyne et al., 2017)
FBrf0236825-3.coIP.PCR
Reference
Coyne et al., 2017
Description
physical association
Assay
Collection
Source/Stage
motor neuron / adult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Hsap\TARDBP 

TDP-43

bait

YFP tag

Hsap\TARDBP 
Hsc70-4 

Hsc70-4

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Hsap\TARDBP 
interaction domain residue 2987
mutation increasing interaction
aa 298

G298S

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adults of transgenic fly line expressing Hsap\TARDBP in motor neurons; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Coyne et al., 2017)
External Crossreferences and Linkouts ( 0 )
References (1)