Su, T.T., Vidwans, S.J. (2000). DNA defects target the centrosome.  Nat. Cell Biol. 2(2): E28--E29.

FBrf0128820

Note

When cells enter mitosis with DNA that is unfit to be segregated, the consequences appear to be loss of centrosome function, abnormal spindles and a failure to segregate chromosomes. These defects may result from the workings of a surveillance mechanism that acts to cull irreparable nuclei.