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Citation
Chen, P.L., Clandinin, T.R. (2008). The cadherin Flamingo mediates level-dependent interactions that guide photoreceptor target choice in Drosophila.  Neuron 58(1): 26--33.
FlyBase ID
FBrf0204321
Publication Type
Research paper
Abstract

Quantitative differences in cadherin activity have been proposed to play important roles in patterning connections between pre- and postsynaptic neurons. However, no examples of such a function have yet been described, and the mechanisms that would allow such differences to direct growth cones to specific synaptic targets are unknown. In the Drosophila visual system, photoreceptors are genetically programmed to make a complex, stereotypic set of synaptic connections. Here we show that the atypical cadherin Flamingo functions as a short-range, homophilic signal, passing between specific R cell growth cones to influence their choice of postsynaptic partners. We find that individual growth cones are sensitive to differences in Flamingo activity through opposing interactions between neighboring cells and require these interactions to be balanced in order to extend along the appropriate trajectory.

PubMed ID
PubMed Central ID
PMC2494600 (PMC) (EuropePMC)
Related Publication(s)
Note

Of cartridges and columns: new roles for cadherins in visual system development.
Matthews et al., 2008, Neuron 58(1): 1--3 [FBrf0204226]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (8)
    Genes (3)
    Insertions (2)
    Transgenic Constructs (3)
    Transcripts (1)