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Citation
Donlea, J.M., Pimentel, D., Miesenböck, G. (2014). Neuronal machinery of sleep homeostasis in Drosophila.  Neuron 81(4): 860--872.
FlyBase ID
FBrf0224193
Publication Type
Research paper
Abstract

Sleep is under homeostatic control, but the mechanisms that sense sleep need and correct sleep deficits remain unknown. Here, we report that sleep-promoting neurons with projections to the dorsal fan-shaped body (FB) form the output arm of Drosophila's sleep homeostat. Homeostatic sleep control requires the Rho-GTPase-activating protein encoded by the crossveinless-c (cv-c) gene in order to transduce sleep pressure into increased electrical excitability of dorsal FB neurons. cv-c mutants exhibit decreased sleep time, diminished sleep rebound, and memory deficits comparable to those after sleep loss. Targeted ablation and rescue of Cv-c in sleep-control neurons of the dorsal FB impair and restore, respectively, normal sleep patterns. Sleep deprivation increases the excitability of dorsal FB neurons, but this homeostatic adjustment is disrupted in short-sleeping cv-c mutants. Sleep pressure thus shifts the input-output function of sleep-promoting neurons toward heightened activity by modulating ion channel function in a mechanism dependent on Cv-c.

PubMed ID
PubMed Central ID
PMC3969244 (PMC) (EuropePMC)
Related Publication(s)
Erratum

Neuronal Machinery of Sleep Homeostasis in Drosophila.
Donlea et al., 2014, Neuron 81(6): 1442 [FBrf0250708]

Personal communication to FlyBase

Location data for three P{GawB} insertions.
Donlea and Miesenboeck, 2017.7.16, Location data for three P{GawB} insertions. [FBrf0236115]

Note

A Drosophila circuit feels the (sleep) pressure.
Ozcan and Rihel, 2014, Neuron 81(4): 720--722 [FBrf0224195]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Neuron
    Title
    Neuron
    Publication Year
    1988-
    ISBN/ISSN
    0896-6273
    Data From Reference
    Alleles (11)
    Genes (4)
    Insertions (3)
    Transgenic Constructs (3)
    Transcripts (3)