FB2026_02 , released June 18, 2026
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Citation
Quigley, T.P., Amdam, G.V. (2021). Social modulation of ageing: mechanisms, ecology, evolution.  Philos. Trans. R. Soc. Lond. B. Biol. Sci. 376(1823): 20190738.
FlyBase ID
FBrf0248300
Publication Type
Review
Abstract
Human life expectancy increases, but the disease-free part of lifespan (healthspan) and the quality of life in old people may not show the same development. The situation poses considerable challenges to healthcare systems and economies, and calls for new strategies to increase healthspan and for sustainable future approaches to elder care. This call has motivated innovative research on the role of social relationships during ageing. Correlative data from clinical surveys indicate that social contact promotes healthy ageing, and it is time to reveal the causal mechanisms through experimental research. The fruit fly Drosophila melanogaster is a prolific model animal, but insects with more developed social behaviour can be equally instrumental for this research. Here, we discuss the role of social contact in ageing, and identify lines of study where diverse insect models can help uncover the mechanisms that are involved. This article is part of the theme issue 'Ageing and sociality: why, when and how does sociality change ageing patterns?'
PubMed ID
PubMed Central ID
PMC7938163 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Philos. Trans. R. Soc. Lond. B. Biol. Sci.
    Title
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
    Publication Year
    1887-
    ISBN/ISSN
    0962-8436 1471-2970
    Data From Reference
    Genes (11)