Utomo, R.Y., Sugie, A., Okada, S., Miura, K., Nakamura, H. (2022). Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model. Chem. Commun. (Camb.) 58(15): 2576--2579.
FlyBase ID
FBrf0252728
Publication Type
Research paper
Abstract
Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.
