Patterson, M., Andrus, A.R., Bell, C., Bromell, J.J., Buchanan, D., Chammout, D.H., Charles, W.X., Cummings, J.E., Dabesh, A., Deleon Garcia, N., Dickerson, K.W., Emiko, T.R., Fathi, S., Floyd, T.J., Gragg, H., Griffin, S.B., Heininger, L., Ibrahim, A., Ivey, C., Jackson, A., Jackson, L., Jeeva, D., Jones, L.E., Kana, K., Kemp, A.S., Khan, A., Kowal, M.R., Kowaleski, S.J., Lago, T.C., Lynch, E., Maalhagh Fard, S., Makki, K., Moaikel, T., Mosby, J.M., Ricketts, D.A., Saho, R.J., Sanchez, F., Sauerbrey, C.H., Sprowl, P.C., Sullivan, K.M., Thomas, M., Tripette, J.J., Ugbaja, C., Volcy, G.A., Watson, J., Williams, D., Bieser, K.L., Peister, A., Siders, J., Kagey, J.D. (2025). The M.3.2 mutation in Drosophila melanogaster mapped as a novel allele of tout-velu.  MicroPubl Biol 2025(): .

FBrf0261763

Research paper

In Drosophila melanogaster genetic screens are often used to identify genes associated with different biological processes. Here, we have utilized the Flp/FRT system to generate mitotic clones within the developing eye. These clones were screened for mutations that disrupt cell division, organ patterning, and cell growth. One such mutation from this screen, mutant M.3.2, resulted in an expansion of the cuticle within the area normally covered by ommatidium as well as an overall smaller eye size. Genetic and molecular mapping revealed this mutation to be in the gene, t out-velu (ttv).

PMC11868921 (PMC) (EuropePMC)