Nair, A., Yearwood, A.J., Besednjak, B.N., Cully, M.M., Turner, R., Bedont, J.L. (2025). Cold-raising unmasks sleep disruption in a Drosophila Alzheimer's disease model. MicroPubl Biol 2025(): .
FlyBase ID
FBrf0262821
Publication Type
Research paper
Abstract
Chronic sleep loss is a risk factor for Alzheimer's disease (AD), and reduced and fragmented sleep is increasingly appreciated as an early-onset diagnostic and potential therapeutic target for AD. However, robustly modeling AD-like sleep deficits in fruit flies has often been challenging. We report that cold-raising unmasks deficits in sleep duration, fragmentation, and latency in one such model pan-neuronally expressing a highly pathogenic AD-associated amyloid species. This sensitized model provides a promising platform for identifying potential metabolic, proteostatic, glymphatic, and other candidate mediators bidirectionally linking sleep and AD.
