FlyBase Natural Transposon Report: Dmel\Doc

General Information

Symbol

Doc

Species

D. melanogaster

Feature type

natural_transposable_element

FlyBase ID

FBte0000341

Sequences and Components

Complete element (bp)

to 5kb

4725

(Kaminker et al., 2002)

Terminal repeat (bp)

Reference sequence

transposon_sequence_set.fa.gz transposon_sequence_set.gff.gz

Component genes

Doc\gag

Doc\RTase

Sequence Accessions

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

Sequence Ontology (SO)

Transposon type

non_LTR_retrotransposon

(Lipatov et al., 2005, Dimitri et al., 2003, Yang and Nuzhdin, 2003, Kaminker et al., 2002)

Insertions and Copy Number

Copy number and comments

55 in euchromatin of Release 3 genome annotation, of which 30 are full length.

(Kaminker et al., 2002)

Search for

Target Site Duplication

Size (bp)

6-13

Orthologs

Curated drosophilid orthologs

Dhyd\Doc

Dmau\Doc

Dsim\Doc

Comments

The Doc element is transcribed as a full-length 5kb transcript which encodes two open reading frames (ORFs). Doc\gag (ORF1) encodes an RNA-binding protein and Doc\RTase (ORF2) encodes a reverse transcriptase. The RNA is localised on the Drosophila oocyte cytoskeleton.

(Zhao and Bownes, 1998)

Changes introduced in the promoter regions of distinct LINEs allows transcriptional activators to stimulate cryptic Inr modules. The response of different promoter constructs to the same enhancer is significantly influenced by the number, position and type of core elements present.

(Minchiotti and Di Nocera, 1997)

F-element, I-element and Doc basal promoters share the same architecture and functional organisation.

(Minchiotti et al., 1997)

Correlations between the rate of transposition and TE copy number are determined for Doc and are found to be positive.

(Nuzhdin et al., 1997)

Doc elements are located in both euchromatin and heterochromatin.

(Terrinoni et al., 1997)

One of a class of genes with TATA-less promoters that have the conserved DPE sequence.

(Burke and Kadonaga, 1996)

Distinct cis-acting DNA elements, clustered in a 50bp long DNA region located at the 5' end of unit-length Doc copies, cooperate to control RNA initiation. Sequences located 200bp downstream from the 5' end inhibit expression in a position and orientation-dependent manner. Inhibition appears to be due to reduced translation rather that to impaired synthesis.

(Contursi et al., 1995)

The distribution of transposable elements within heterochromatin indicates that they are major structural components of the heterochromatin.

(Pimpinelli et al., 1995)

Ectopic recombination can occur between two Doc elements.

(Lim and Simmons, 1994)

The Doc retrotransposon has been found unstable in certain stocks.

(Pasyukova and Nuzhdin, 1993)

Closely related to I-element, F-element, G-element and jockey element.

(O'Hare et al., 1991)

There is no sequence homology between the ends of the Doc element. Different Doc elements are conserved at the 3' end (which terminates with a polyadenylation signal followed by a stretch of oligo-A), but may be truncated at the 5' end, suggesting a mechanism of transposition via an RNA intermediate.

(Driver et al., 1989)

Doc elements lie at both break points of the Antp^73b inversion; these elements lie in inverted orientation and the inversion probably resulted from recombination between them.

(Schneuwly et al., 1987)

First described as an insertion in the BXC region on a chromosome carrying the Ubx^bx-3 mutation, although it is not responsible for the mutant phenotype.

(Bender et al., 1983)

Other Information

Etymology

External Crossreferences and Linkouts ( 8 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

DOC

(Rigal et al., 2022, Saint-Leandre et al., 2020, Chang et al., 2019, Olivieri et al., 2012, Zhou et al., 2009, Czech et al., 2008, Gunawardane et al., 2007, Kapitonov and Jurka, 2003)

Doc

(Wierzbicki et al., 2023, Andreev et al., 2022, Wang et al., 2022, de Oliveira et al., 2021, Fabry et al., 2021, Huang et al., 2021, Yu et al., 2021, Cavaliere et al., 2020, Chang et al., 2019, Rech et al., 2019, Lee et al., 2018, Théron et al., 2018, Khost et al., 2017, Hayashi et al., 2016, Iwasaki et al., 2016, González et al., 2015, Kofler et al., 2015, Molla-Herman et al., 2015, Rahman et al., 2015, Senti et al., 2015, Basquin et al., 2014, Blumenstiel et al., 2014, Huang et al., 2014, Kim et al., 2014, Sytnikova et al., 2014, Dönertas et al., 2013, Vagin et al., 2013, Zanni et al., 2013, Kofler et al., 2012, Sienski et al., 2012, Handler et al., 2011, Klenov et al., 2011, Méndez-Lago et al., 2011, Pane et al., 2011, Petrov et al., 2011, Wang and Elgin, 2011, Zhang et al., 2011, Cooper et al., 2010, Lu and Clark, 2010, Deloger et al., 2009, Lau et al., 2009, Li et al., 2009, Phalke et al., 2009, Chambeyron et al., 2008, Ghildiyal et al., 2008, González et al., 2008, Iklé et al., 2008, Kawamura et al., 2008, Bergman and Bensasson, 2007, Brennecke et al., 2007, Gunawardane et al., 2007, Lecuyer et al., 2007, Smith et al., 2007, Bergman et al., 2006, ffrench-Constant et al., 2006, Lipatov et al., 2005, Mito et al., 2005, Dimitri et al., 2003, Fanti et al., 2003, Yang and Nuzhdin, 2003)

Doc element

(Cooper et al., 2010)

Doc-element

(Sun et al., 2012, Kretova et al., 2002)

Doc1053

(Yenerall et al., 2011)

Doc1420

(Cogni et al., 2016)

Docmel

(Casacuberta and Pardue, 2003)

EG:121E7.1

EG:80H7.8

TE Doc

(Kearney et al., 2004)

doc

(Patil et al., 2014, Czech et al., 2013, Ohtani et al., 2013, Malone et al., 2009, Brennecke et al., 2008, Macpherson et al., 2008, Fablet et al., 2007)

doc element

(Mackay et al., 1994)

Secondary FlyBase IDs

FBgn0000481
FBtp0011424

References (189)

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