Construct: Amino acid replacement: H?R. Nucleotide substitution: TTTCAC?TTTCGC Amino acid replacement: C?S. Nucleotide substitution: AACTGC?AACTCC Amino acid replacement: C?S. Nucleotide substitution: TGCTGC?TGCTCC Amino acid replacement: C?S. Nucleotide substitution: GTCTGC?GCCTCC