FB2026_03 , released September 17, 2026
Recombinant Construct: M{UAS-Hnf4.R167W.S169A}
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General Information
Symbol
M{UAS-Hnf4.R167W.S169A}
FlyBase ID
FBtp0141206
Feature type
transgenic_transposable_element
Component Allele(s)
Hnf4R167W.S169A.UAS.Tag:HA
Size
Expression Data
Associated insertion(s)
1 available
Molecular map
Description and Uses
Construct components
Component allele Hnf4R167W.S169A.UAS.Tag:HA
Transgenic product class
missense_variant
(Marchesin et al., 2019)
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hnf4
Tagged with
Tag:HA
Description

UAS regulates expression of the Tag:HA-tagged Hnf4 ORF containing the R167W mutation, which corresponds to the R85W mutation in human 'HNF4A' (aka'MODY1') associated with Fanconi renotubular syndrome (FRTS). This construct also contains a S169A mutation, which is equivalent to S87A in human 'HNF4A' (aka'MODY1'), thus suppressing PKC-dependent phosphorylation at that position and thereby also suppressing Hnf4 nuclear export and consequent cytotoxic effects.

(Marchesin et al., 2019)
Sequence Data
Sequence (FB)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA Sequence
Extent
Segments and Size
Total Size
Left end
Right end
 
Segments
Num
Orientation
Symbol
Reference
Phenotypic Data
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Progenitors and Descendants
progenitor(s)
descendant(s)
Comments
Stocks (0)
Stocks containing insertion(s) of this recombinant construct
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
M{UAS-Hnf4.R167W.S169A}
(FlyBase, 1992-)
UAS-dHNF4R167W/S169A
(Marchesin et al., 2019)
Secondary FlyBase IDs
    References (3)