FlyBase Recombinant Construct Report: P{UAS-Aβ1-42.Cry2-mCh}

UAS regulatory sequences drive expression of a fusion protein composed of the Aβ1-42 peptide tagged with CRY2(PHR) and mCherry. A CRY2(PHR)-mCherry fusion protein has previously been shown to oligomerize in response to blue light of 488nm (PMID:23377377). In this transgene, the presence of the CRY2(PHR)-mCherry part of the fusion protein allows irreversible light-induced clustering of the Aβ1-42 peptide.

(Lim et al., 2020)

Sequence Data

Sequence (FB)

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA Sequence

Extent

Segments and Size

Total Size

Left end

Right end

Segments

Num

Orientation

Symbol

Reference

Phenotypic Data

Component Allele

Phenotypic Data

Hsap\APP^{1-42.UAS.CRY2(PHR),mCherry}

Phenotypic Class Phenotype Manifest In Detailed Description

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Progenitors and Descendants

progenitor(s)

descendant(s)

Comments

Stocks (0)

Stocks containing insertion(s) of this recombinant construct

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

P{UAS-Aβ1-42.Cry2-mCh}

(FlyBase, 1992-)

UAS-Aβ-CRY2-mCh

(Kaur et al., 2022)

UAS-Aβ-Cry2-mCh

(Lim et al., 2020)

UAS-Aβ^1-42-CRY2-mCh

(Kaur et al., 2022)

Secondary FlyBase IDs

References (4)

Report Sections

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