FB2026_02 , released June 18, 2026
Allele: Hsap\APP1-42.UAS.CRY2(PHR),mCherry
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General Information
Symbol
Hsap\APP1-42.UAS.CRY2(PHR),mCherry
Species
H. sapiens
Name
FlyBase ID
FBal0360097
Feature type
allele
Associated gene
Hsap\APP
Associated Insertion(s)
Carried in Construct
P{UAS-Aβ1-42.Cry2-mCh}
Also Known As
UAS-Aβ-Cry2-mCh
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Lim et al., 2020)
Progenitor genotype
Carried in construct
P{UAS-Aβ1-42.Cry2-mCh}
Cytology
Description

UAS regulatory sequences drive expression of a fusion protein composed of the Aβ1-42 peptide tagged with CRY2(PHR) and mCherry. A CRY2(PHR)-mCherry fusion protein has previously been shown to oligomerize in response to blue light of 488nm (PMID:23377377). In this transgene, the presence of the CRY2(PHR)-mCherry part of the fusion protein allows irreversible light-induced clustering of the Aβ1-42 peptide.

(Lim et al., 2020)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\APP
Tagged with
CRY2(PHR)
mCherry
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Alzheimer's disease 1
      CEA
      (Kaur et al., 2022, Lim et al., 2020)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Alzheimer's disease 1
      is ameliorated by wgUAS.cHa.Tag:HA
      (Kaur et al., 2022)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\APP1-42.UAS.CRY2(PHR),mCherry
      Name Synonyms
      Secondary FlyBase IDs
        References (2)