FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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Term lyase activity ID (Ontology) GO:0016829 (Gene Ontology)
Definition Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.[ EC:4 ]
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Genes (FBgn)GO_MOLECULAR_FUNCTION
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 lyase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | lyase activity       --
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  molecular_function
   |__catalytic activity
       |__lyase activity  167 rec.
           |__3'-deoxyribose phosphate lyase activity
           |__alkylmercury lyase activity
           |__carbon phosphorus lyase activity
           |   |__alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase activity
           |__carbon-carbon lyase activity 41 rec.
           |   |__2-iminoacetate synthase activity
           |   |__3,4-dihydroxy-2-butanone-4-phosphate synthase activity
           |   |__aldehyde oxygenase (deformylating) activity
           |   |__aldehyde-lyase activity(+) 7 rec.
           |   |__benzylsuccinate synthase activity
           |   |__carboxy-lyase activity(+) 24 rec.
           |   |__DNA photolyase activity(+) 3 rec.
           |   |__GTP 3',8'-cyclase activity 1 rec.
           |   |__long-chain fatty aldehyde oxidative decarbonylase activity 2 rec.
           |   |__oxo-acid-lyase activity(+) 1 rec.
           |   |__phosphomethylpyrimidine synthase activity
           |   |__tryptophanase activity
           |   |__tyrosine phenol-lyase activity
           |__carbon-halide lyase activity 2 rec.
           |   |__3-chloro-D-alanine dehydrochlorinase activity
           |   |__DDT-dehydrochlorinase activity 1 rec.
           |   |__dichloromethane dehalogenase activity
           |   |__DIF dechlorinase activity
           |   |__halohydrin hydrogen-halide-lyase activity
           |   |__L-2-amino-4-chloropent-4-enoate dehydrochlorinase activity
           |   |__L-propargylglycine synthase activity
           |   |__S-carboxymethylcysteine synthase activity
           |__carbon-nitrogen lyase activity 14 rec.
           |   |__amidine-lyase activity(+) 11 rec.
           |   |__amine-lyase activity(+)
           |   |__ammonia-lyase activity(+) 2 rec.
           |   |__choline trimethylamine lyase activity
           |__carbon-oxygen lyase activity 63 rec.
           |   |__2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
           |   |__5'-deoxyribose-5-phosphate lyase activity 3 rec.
           |   |__carbon-oxygen lyase activity, acting on phosphates(+) 3 rec.
           |   |__carbon-oxygen lyase activity, acting on polysaccharides(+)
           |   |__carboxymethyloxysuccinate lyase activity
           |   |__class I DNA-(apurinic or apyrimidinic site) endonuclease activity 6 rec.
           |   |__hydro-lyase activity(+) 50 rec.
           |   |__isochorismate pyruvate lyase activity
           |   |__O-acetylhomoserine sulfhydrylase activity
           |__carbon-sulfur lyase activity 5 rec.
           |   |__1-aminocyclopropane-1-carboxylate synthase activity
           |   |__2-hydroxypropyl-CoM lyase activity
           |   |__alliin lyase activity
           |   |__cystathionine gamma-lyase activity 1 rec.
           |   |__cysteine lyase activity
           |   |__cysteine sulfinate desulfinase activity
           |   |__cysteine-S-conjugate beta-lyase activity 1 rec.
           |   |__D-cysteine desulfhydrase activity
           |   |__dimethylpropiothetin dethiomethylase activity
           |   |__eoxin C4 synthase activity
           |   |__hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
           |   |__holocytochrome-c synthase activity 1 rec.
           |   |__homocysteine desulfhydrase activity
           |   |__L-3-cyanoalanine synthase activity
           |   |__L-cysteate sulfo-lyase activity
           |   |__L-cysteine desulfhydrase activity
           |   |__L-cystine L-cysteine-lyase (deaminating) activity
           |   |__lactoylglutathione lyase activity 1 rec.
           |   |__leukotriene-C4 synthase activity
           |   |__methionine gamma-lyase activity
           |   |__phosphosulfolactate synthase activity
           |   |__S-(hydroxymethyl)glutathione synthase activity
           |   |__S-adenosyl-L-methionine lyase activity
           |   |__S-alkylthiohydroximate lyase activity
           |   |__S-ribosylhomocysteine lyase activity
           |   |__selenocystathionine gamma-lyase activity
           |   |__selenocysteine lyase activity
           |   |__selenomethionine gamma-lyase activity
           |   |__sulfolactate sulfo-lyase activity
           |__nitrogen-oxygen lyase activity
           |   |__aliphatic aldoxime dehydratase activity
           |   |__indoleacetaldoxime dehydratase activity
           |   |__phenylacetaldoxime dehydratase activity
           |__phosphorus-oxygen lyase activity 39 rec.
           |   |__2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
           |   |__adenylate cyclase activity(+) 14 rec.
           |   |__cyclic pyranopterin monophosphate synthase activity 1 rec.
           |   |__cytidylate cyclase activity
           |   |__Enterobacter ribonuclease activity
           |   |__FAD-AMP lyase (cyclizing) activity
           |   |__glycosylphosphatidylinositol diacylglycerol-lyase activity
           |   |__guanylate cyclase activity 17 rec.
           |   |__phosphatidylinositol diacylglycerol-lyase activity
           |   |__ribonuclease A activity
           |   |__ribonuclease T1 activity
           |   |__ribonuclease T2 activity 2 rec.
           |   |__ribonuclease U2 activity
           |   |__rRNA endonuclease activity
           |   |__tRNA-intron lyase activity 3 rec.
           |__protein-DNA covalent cross-linking activity 1 rec.
           |__protoporphyrin ferrochelatase activity 1 rec.
           |__sirohydrochlorin cobaltochelatase activity
           |__sirohydrochlorin ferrochelatase activity
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EC:4.-.-.-
Reactome:R-HSA-5696408 "PXLP-K278-PHYKPL tetramer hydrolyses 5PHL"
Reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)"