FlyBase Allele Report: Dmel\cno[3]

General Information

Symbol

Dmel\cno³

Species

D. melanogaster

Name

FlyBase ID

FBal0001749

Feature type

allele

Associated gene

Dmel\cno

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Tearle and Nusslein-Volhard, 1987)

Progenitor genotype

Cytology

Description

Amino acid replacement: Q140term.

(Gurley et al., 2023)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:5,202,577..5,202,577 [-]

Nucleotide change:

C5202577T

Amino acid change:

Reported amino acid change:

Q140term

Comment:

Site and nature of nucleotide substitution in mutant inferred by FlyBase curator based on reported amino acid change.

(Gurley et al., 2023)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

cone cell

(Matsuo et al., 1997)

embryo

(Gurley et al., 2023)

embryonic/first instar larval cuticle | dorsal

(Takahashi et al., 1998)

embryonic head

(Gurley et al., 2023)

pigment cell

(Matsuo et al., 1997)

Detailed Description

Statement

Reference

Homozygous embryos have a dorsal open phenotype. The leading edge cells show little elongation during stage 15 (at or slightly before completion of dorsal closure). cno^mis1/cno³ embryos have no apparent defects in dorsal closure.

(Takahashi et al., 1998)

Transheterozygotes cno^mis1/cno³ have a roughened eye structure.

(Miyamoto et al., 1995)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

cno³ is an enhancer of abnormal cell polarity phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

Suppressor of

Statement

Reference

cno³/cno[+] is a suppressor of visible | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Phenotype Manifest In

Suppressed by

Statement

Reference

cno³ has embryonic/first instar larval cuticle | dorsal phenotype, suppressible by bsk^hs.PS

(Takahashi et al., 1998)

Enhancer of

Statement

Reference

cno³ is an enhancer of ommatidium phenotype of S^48-5

(Gaengel and Mlodzik, 2003)

cno³ is an enhancer of phenotype of Ras85D^V12.sev

(Matsuo et al., 1997)

cno³ is an enhancer of phenotype of Ras64B^V12.sev

(Matsuo et al., 1997)

NOT Enhancer of

Statement

Reference

cno³/cno[+] is a non-enhancer of ommatidium phenotype of faf^FO8/faf^BX3

(Chen et al., 2000)

Suppressor of

Statement

Reference

cno³/cno[+] is a suppressor of wing vein | ectopic | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

cno³/cno[+] is a suppressor of wing | heat sensitive phenotype of H^C2.hs

(Johannes and Preiss, 2002)

Other

Statement

Reference

bsk², cno^mis1/cno³ has embryonic/first instar larval cuticle | dorsal phenotype

(Takahashi et al., 1998)

cno^mis1/cno³, hep¹ has embryonic/first instar larval cuticle | dorsal phenotype

(Takahashi et al., 1998)

cno^mis1/cno³, hep[+]/hep¹ has embryonic/first instar larval cuticle | dorsal phenotype

(Takahashi et al., 1998)

bsk²/bsk[+], cno^mis1/cno³ has embryonic/first instar larval cuticle | dorsal phenotype

(Takahashi et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

S^48-5/cno³ mutants show 43.24%+-8.67 misrotated ommatidia compared to 9.55%+-1.43 seen in S^48-5 mutants alone.

(Gaengel and Mlodzik, 2003)

The dorsal open phenotype of cno³ homozygous embryos is partly suppressed by bsk^hs.PS. hep¹ and bsk² dominantly enhance the cno^mis1/cno³ phenotype; hep¹/+; cno^mis1/cno³ and bsk²/+; cno^mis1/cno³ embryos have a dorsal open phenotype. Dorsal closure proceeds normally in puc^E69 cno³ double heterozygotes.

(Takahashi et al., 1998)

Loss of cno⁺ activity (cno³ or Df(3R)6-7) in Ras85D^V12.sev flies does not affect overproduction of R7 cells but loss of pigment cells is more severe and supernumerary cone cells appear (these cone cells are recruited from a pool of retinal precursors that normally develop into pigment cells and from cells to be eliminated by apoptosis). The phl¹ mutation completely suppresses the overproduction of cone cells triggered by the Ras85D^V12.sev and cno³ interaction.

(Matsuo et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

109029

w^*; cno³ P{A92}puc^E69 / TM6B,abdA-LacZ

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

canoe^10B1

(Matsuo et al., 1999)

cno-3

(Gaengel and Mlodzik, 2003)

cno^10B01

(Miyamoto et al., 1995)

cno^10B1

(Matsuo et al., 1997, Matsuo et al., 1997, Tearle and Nusslein-Volhard, 1987)

cno³

(Gurley et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections

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