|Feature type||allele||Associated gene||Dmel\scb|
|Also Known As||scbIIG|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
The cardioblasts of the heart region of the dorsal vessel in homozygous stage embryos show a less regular alignment of their nuclei along the midline in mutant embryos compared to wild type. No lumen develops between contralaterally apposed cardioblasts in the heart region of mutant embryos, in contrast to wild type. The leading edge membrane of migrating mutant cardioblasts shows less vigorous activity than that of wild-type cardioblasts.
Mutant embryos have no severe defects in salivary gland shape or positioning.
Germ-line clones exhibit a U shaped embryonic phenotype at low penetrance (about 4.5%) suggesting germ band retraction defects. scb5J38/scb2 embryos also exhibit a U shaped embryonic phenotype at low penetrance (about 4%). scb2/Df(2R)Jp1 show the same phenotype at 11% penetrance.
The germ band twists laterally, rather than extending dorsally as in wild type. Proper orientation of the germ band in recovered by the completion of germ-band extension. Embryos exhibit mislocalisation of the pericardial cells and there are fewer of these cells than in wild type. Embryos exhibit significant gaps in the dorsal trunk of the trachea. Embryos frequently display one salivary gland misshapen and smaller than the other, the gland may also be shifted closer to the midline.
|NOT Suppressor of|
|Phenotype Manifest In|
mys/+ ; scb/+ and vkg[p1003-83]/scb double heterozygous embryos show defects in continuity and alignment of the cardioblasts at the dorsal midline. LanA[9-32]/+ ; scb/+ and wb[SF11]/scb double heterozygous embryos show defects in alignment of the cardioblasts at the dorsal midline.
Significant overgrowth of the neuromuscular junction (NMJ) (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in scb/+ Fak[N30]/Fak[KG00304] third instar larvae.
Heterozygosity for scb2 does not result in lethality in Abl1/+ embryos derived from homozygous Abl1 female germline clones.
ifB4 scb2 double mutant embryos show no difference in midgut development compared to ifB4 single mutant embryos. mewM6 scb2 double mutant embryos show a strong defect in the migration of the endodermal midgut cells, with a delay in migration of approximately 2 hours (similar to that observed in embryos lacking both maternal and zygotic mys function).
|Complementation & Rescue Data|
|Fails to complement|
|Partially rescued by|
|Stocks ( 2 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 16 )|
|Personal communication to FlyBase|