Allele Dmel\arm^ΔN.Scer\UAS

General Information
Symbol	Dmel\arm^ΔN.Scer\UAS	Species	D. melanogaster
Name		FlyBase ID	FBal0061503
Feature type	allele	Associated gene	Dmel\arm

Allele class
Mutagen	in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
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Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Pai et al., 1997)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: A truncated arm protein lacking the entire N-terminal domain (amino acids 1 to 128) is expressed under the control of Scer\UAS regulatory sequences. (Pai et al., 1997)
Carried in construct	P{UAS-arm.ΔN} (Buratovich and Wilder, 2001, Buratovich et al., 2000, Nagaraj et al., 1999, Loureiro et al., 2001, Johnston and Edgar, 1998, Pai et al., 1997, Bhanot et al., 1999, Franch-Marro et al., 2006, Estella et al., 2008, Sato et al., 2006, Sinenko et al., 2009, Giorgianni and Mann, 2011)
Cytology
Phenotypic Data
Phenotypic Class
	mitotic cell cycle defective, with Scer\GAL4^bbg-C96 (Johnston and Edgar, 1998)
Phenotype Manifest In
	denticle belt, with Scer\GAL4^e22c (Pai et al., 1997) denticle belt, with Scer\GAL4^h-1J3 (Pai et al., 1997) embryonic epidermis, with Scer\GAL4^da.G32 (Bhanot et al., 1999) lymph gland derived hemocyte \| third instar larval stage, with Scer\GAL4^dome-PG14 (Sinenko et al., 2009) wing disc, with Scer\GAL4^bbg-C96 (Johnston and Edgar, 1998) wing disc, with Scer\GAL4^dpp.blk1 (Nagaraj et al., 1999) wing disc, with Scer\GAL4^T80 (Nagaraj et al., 1999)
Detailed Description
	Statement Reference Expression of arm[ΔN.Scer\UAS] under the control of Scer\GAL4[dome-PG14] blocks differentiation of hemocyte precursors in the lymph gland. (Sinenko et al., 2009) Expression of arm[ΔN.Scer\UAS] in the retina behind the furrow using Scer\GAL4[GMR.PF] does not really affect R axon projection, with only a few mild misroutings found. (Sato et al., 2006) When arm^ΔN.Scer\UAS is driven by Scer\GAL4^c306 or Scer\GAL4^slbo.2.6 no effect is seen on border cell migration. (Loureiro et al., 2001) Expression of arm^ΔN.Scer\UAS under the control of Scer\GAL4^da.G32 results in a phenotype identical to that produced by overexpression of wg. (Buratovich et al., 2000) When expression is driven by Scer\GAL4^da.G32 the embryonic cuticle is devoid of denticles. (Bhanot et al., 1999) Expression of arm^ΔN.Scer\UAS under the control of either Scer\GAL4^dpp.blk1 or Scer\GAL4^T80 causes conversion of notum to pouch tissue in the wing disc, but no ectopic growth in the pouch is seen. (Nagaraj et al., 1999) Causes G2 arrest in the ZNC of the developing wing. (Johnston and Edgar, 1998) Expression of arm^ΔN.Scer\UAS using Scer\GAL4^e22c gives rise to embryos with partially ablated denticle belts, especially along the ventral midline. Embryos expressing arm^ΔN.Scer\UAS using Scer\GAL4^h-1J3 have fewer denticles in many even-numbered segments. (Pai et al., 1997)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference When expression is driven by Scer\GAL4^da.G32 in a fz²¹, Df(3L)fz2 or fz²³, Df(3L)fz2 mutant background the embryonic cuticle is devoid of denticles. (Bhanot et al., 1999) wg^l-8 embryos expressing arm^ΔN.Scer\UAS (using Scer\GAL4^e22c) secrete naked cuticle interspersed with denticles on their ventral surface, while the dorsal surface is unchanged from the wg^l-8 mutant phenotype. (Pai et al., 1997)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	arm^ΔN.Scer\UAS arm^ΔN.UAS arm^ΔN (Pai et al., 1997)
Name Synonym
Secondary FlyBase IDs

References ( 12 )
Research paper	Giorgianni and Mann, 2011, Dev. Cell 20(4): 455--468 Establishment of Medial Fates along the Proximodistal Axis of the Drosophila Leg through Direct Activation of dachshund by Distalless. [FBrf0213490] Sinenko et al., 2009, Dev. Cell 16(5): 756--763 Dual role of wingless signaling in stem-like hematopoietic precursor maintenance in Drosophila. [FBrf0207962] Estella et al., 2008, Dev. Cell 14(1): 86--96 Molecular integration of wingless, decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development. [FBrf0202802] Franch-Marro et al., 2006, Development 133(5): 785--790 Association of tracheal placodes with leg primordia in Drosophila and implications for the origin of insect tracheal systems. [FBrf0190289] Sato et al., 2006, Nat. Neurosci. 9(1): 67--75 DWnt4 regulates the dorsoventral specificity of retinal projections in the Drosophila melanogaster visual system. [FBrf0191282] Buratovich and Wilder, 2001, D. I. S. 84: 145--157 The role of wingless in the development of the proximal wing hinge of Drosophila. [FBrf0150733] Loureiro et al., 2001, Dev. Biol. 235(1): 33--44 Activated armadillo/beta-catenin does not play a general role in cell migration and process extension in Drosophila. [FBrf0136851] Buratovich et al., 2000, Dev. Genes Evol. 210(3): 111--119 DWnt-4 and wingless have distinct activities in the Drosophila dorsal epidermis. [FBrf0125145] Bhanot et al., 1999, Development 126(18): 4175--4186 Frizzled and DFrizzled-2 function as redundant receptors for wingless during Drosophila embryonic development. [FBrf0111329] Nagaraj et al., 1999, Development 126(5): 975--985 Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial. [FBrf0107900] Johnston and Edgar, 1998, Nature 394(6688): 82--84 Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. [FBrf0102947] Pai et al., 1997, Development 124(11): 2255--2266 Negative regulation of Armadillo, a Wingless effector in Drosophila. [FBrf0093638]

Allele Dmel\armΔN.Scer\UAS

Allele Dmel\arm^ΔN.Scer\UAS