FlyBase Allele Report: Dmel\arm[ΔN.UAS]

General Information

Symbol

Dmel\arm^ΔN.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0061503

Feature type

allele

Associated gene

Dmel\arm

Associated Insertion(s)

Carried in Construct

P{UAS-arm.ΔN}

Also Known As

UAS-Arm^ΔN, UAS-arm (delta N), UAS-arm^*

Key Links

Transgenic product class

inframe_deletion

(Pai et al., 1997)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Pai et al., 1997)

Mutagen

in vitro construct

(Pai et al., 1997)

Progenitor genotype

Carried in construct

P{UAS-arm.ΔN}

Cytology

Description

A truncated arm protein lacking the entire N-terminal domain (amino acids 1 to 128) is expressed under the control of UASt regulatory sequences.

(Pai et al., 1997)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

arm

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle, with Scer\GAL4^bbg-C96

(Johnston and Edgar, 1998)

Phenotype Manifest In

embryonic epidermis, with Scer\GAL4^da.G32

(Bhanot et al., 1999)

lymph gland derived hemocyte | third instar larval stage, with Scer\GAL4^dome-PG14

(Sinenko et al., 2009)

ventral denticle belt, with Scer\GAL4^e22c

(Pai et al., 1997)

ventral denticle belt, with Scer\GAL4^h-1J3

(Pai et al., 1997)

wing disc, with Scer\GAL4^bbg-C96

(Johnston and Edgar, 1998)

wing disc, with Scer\GAL4^dpp.blk1

(Nagaraj et al., 1999)

wing disc, with Scer\GAL4^T80

(Nagaraj et al., 1999)

Detailed Description

Statement

Reference

Expression of arm^ΔN.Scer\UAS under the control of Scer\GAL4^dome-PG14 blocks differentiation of hemocyte precursors in the lymph gland.

(Sinenko et al., 2009)

Expression of arm^ΔN.Scer\UAS in the retina behind the furrow using Scer\GAL4^GMR.PF does not really affect R axon projection, with only a few mild misroutings found.

(Sato et al., 2006)

When arm^ΔN.Scer\UAS is driven by Scer\GAL4^c306 or Scer\GAL4^slbo.2.6 no effect is seen on border cell migration.

(Loureiro et al., 2001)

Expression of arm^ΔN.Scer\UAS under the control of Scer\GAL4^da.G32 results in a phenotype identical to that produced by overexpression of wg.

(Buratovich et al., 2000)

When expression is driven by Scer\GAL4^da.G32 the embryonic cuticle is devoid of denticles.

(Bhanot et al., 1999)

Expression of arm^ΔN.Scer\UAS under the control of either Scer\GAL4^dpp.blk1 or Scer\GAL4^T80 causes conversion of notum to pouch tissue in the wing disc, but no ectopic growth in the pouch is seen.

(Nagaraj et al., 1999)

Causes G2 arrest in the ZNC of the developing wing.

(Johnston and Edgar, 1998)

Expression of arm^ΔN.Scer\UAS using Scer\GAL4^e22c gives rise to embryos with partially ablated denticle belts, especially along the ventral midline. Embryos expressing arm^ΔN.Scer\UAS using Scer\GAL4^h-1J3 have fewer denticles in many even-numbered segments.

(Pai et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

When expression is driven by Scer\GAL4^da.G32 in a fz²¹, Df(3L)fz2 or fz²³, Df(3L)fz2 mutant background the embryonic cuticle is devoid of denticles.

(Bhanot et al., 1999)

wg^l-8 embryos expressing arm^ΔN.Scer\UAS (using Scer\GAL4^e22c) secrete naked cuticle interspersed with denticles on their ventral surface, while the dorsal surface is unchanged from the wg^l-8 mutant phenotype.

(Pai et al., 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

arm^ΔN.Scer\UAS

arm^ΔN.UAS

arm^ΔN

(Pai et al., 1997)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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