Allele Dmel\Rel^{Scer\UAS.T:Zzzz\His6}

General Information
Symbol	Dmel\Rel^{Scer\UAS.T:Zzzz\His6}	Species	D. melanogaster
Name		FlyBase ID	FBal0102860
Feature type	allele	Associated gene	Dmel\Rel

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Hedengren et al., 1999) in vitro construct - regulatory fusion (Hedengren et al., 1999)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Scer\UAS regulatory sequences drive expression of Rel tagged at the N-terminal end with T:Zzzz\His6. (Hedengren et al., 1999)
Carried in construct	P{UAS-Rel.His6} (Hedengren et al., 1999, Kim et al., 2006, Khush et al., 2002, Ryu et al., 2006, Overend et al., 2012, Leulier et al., 2006, Choi et al., 2008)
Tagged with	T:Zzzz\His6 (Hedengren et al., 1999, Khush et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell number, with Scer\GAL4^cad-md509 (Choi et al., 2008)
Phenotype Manifest In
	adult posterior midgut epithelium (Choi et al., 2008)
Detailed Description
	Statement Reference Expression of Rel[Scer\UAS.T:Zzzz\His6] under the control of Scer\GAL4[cad-md509] increases BrdU incorporation in the large and small cells in the adult posterior midgut, indicating an increase in cellular proliferation. (Choi et al., 2008)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Rel^{Scer\UAS.T:Zzzz\His6}/Scer\GAL4^hs.PB rescues Rel^E20 (Hedengren et al., 1999)
Partially rescues	Rel^{Scer\UAS.T:Zzzz\His6}/Scer\GAL4^c564 partially rescues Rel^E20 (Ryu et al., 2006) Rel^{Scer\UAS.T:Zzzz\His6}/Scer\GAL4^cad-em459 partially rescues Rel^E20 (Ryu et al., 2006)
Comments	Expression of Rel^{Scer\UAS.T:Zzzz\His6} in the intestine, driven by Scer\GAL4^cad-em459, results in the increased survival rate of Rel^E20 flies to control levels following infection with the ROS-resistant KNU53775 yeast strain. However, expression of Rel^{Scer\UAS.T:Zzzz\His6} in the fat body, driven by Scer\GAL4^c564, does not increase the survival rates of Rel^E20 flies following KNU53775 infection. In contrast, expression of Rel^{Scer\UAS.T:Zzzz\His6} increases survival rates of Rel^E20 flies in response to infection with Erwinia carotovora carotovora 15 when driven by Scer\GAL4^c564 but does not increase survival when driven with Scer\GAL4^cad-em459. (Ryu et al., 2006) Rescues the immune defects of Rel^E20 flies when expressed under the control of Scer\GAL4^hs.PB. (Hedengren et al., 1999)
Stocks ( 1 )
Bloomington	9459 w¹¹¹⁸; P{UAS-Rel.His6}2; l(3)^/TM3, Sb¹
Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Rel^{Scer\UAS.T:Zzzz\His6}
Name Synonym
Secondary FlyBase IDs

References ( 7 )
Research paper	Overend et al., 2012, Peptides 34(1): 209--218 The receptor guanylate cyclase Gyc76C and a peptide ligand, NPLP1-VQQ, modulate the innate immune IMD pathway in response to salt stress. [FBrf0217783] Choi et al., 2008, Biochim. Biophys. Acta 1780(10): 1093--1100 Age-related upregulation of Drosophila caudal gene via NF-kappa B in the adult posterior midgut. [FBrf0205747] Kim et al., 2006, Proc. Natl. Acad. Sci. U.S.A. 103(44): 16358--16363 Caspar, a suppressor of antibacterial immunity in Drosophila. [FBrf0194794] Leulier et al., 2006, Mol. Cell. Biol. 26(21): 7821--7831 The Drosophila inhibitor of apoptosis protein DIAP2 functions in innate immunity and is essential to resist gram-negative bacterial infection. [FBrf0192381] Ryu et al., 2006, EMBO J. 25(15): 3693--3701 An essential complementary role of NF-kappaB pathway to microbicidal oxidants in Drosophila gut immunity. [FBrf0193652] Khush et al., 2002, Curr. Biol. 12(20): 1728--1737 A ubiquitin-proteasome pathway represses the Drosophila immune deficiency signaling cascade. [FBrf0151852] Hedengren et al., 1999, Mol. Cell 4(5): 827--837 Relish, a central factor in the control of humoral but not cellular immunity in Drosophila. [FBrf0123041]

Allele Dmel\RelScer\UAS.T:Zzzz\His6

Allele Dmel\Rel^{Scer\UAS.T:Zzzz\His6}