Allele Dmel\InR³⁰⁴

General Information
Symbol	Dmel\InR³⁰⁴	Species	D. melanogaster
Name		FlyBase ID	FBal0122081
Feature type	allele	Associated gene	Dmel\InR

Map ( GBrowse )
Allele class
Mutagen
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen
Mutations Mapped to the Genome

Type Location Additional Notes References point mutation 3R:17,400,787..17,400,788 comment=Mutation is in the cytoplasmic region evidence=experimental pr_change=W1587@\|InR-PA reported_pr_change=W1439@ comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. InR³¹ and InR³⁰⁴ have mutations at adjacent G residues; specific changes for each not reported. (Brogiolo et al., 2001)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Amino acid replacement: W1439@. (Brogiolo et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| larval stage (with InR^93Dj-4) (Oldham et al., 2002) lethal \| larval stage (with InR³²⁷) (Oldham et al., 2002) visible \| somatic clone (Junger et al., 2003)
Phenotype Manifest In
	eye disc \| somatic clone (Bateman and McNeill, 2004) head capsule \| somatic clone (Junger et al., 2003)
Detailed Description
	Statement Reference Homozygous clones in the eye disc (induced using the Minute technique) show a strong delay in differentiation of pros-expressing cells. (Bateman and McNeill, 2004) Head capsule reduced - pinhead phenotype. (Junger et al., 2003) Homozygous mutant clones in the eye disc are smaller than their wild-type sister clones. (Brogiolo et al., 2001)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference InR^93Dj-4/InR³⁰⁴ has lethal \| larval stage phenotype, suppressible \| partially by Pten^2L100/Pten¹¹⁷ (Oldham et al., 2002) InR³⁰⁴ has visible \| somatic clone phenotype, suppressible \| partially by foxo²⁵ (Junger et al., 2003) InR³²⁷/InR³⁰⁴ has lethal \| larval stage phenotype, suppressible \| partially by Pten^2L100/Pten¹¹⁷ (Oldham et al., 2002)
Suppressor of
Statement Reference InR³⁰⁴ is a suppressor of increased cell number phenotype of Ilp2^Scer\UAS.cBa/Ilp2^Scer\UAS.cBa, Scer\GAL4^hs.PB (Brogiolo et al., 2001) InR³⁰⁴ is a suppressor of increased cell size phenotype of Ilp2^Scer\UAS.cBa/Ilp2^Scer\UAS.cBa, Scer\GAL4^hs.PB (Brogiolo et al., 2001) InR³⁰⁴ is a suppressor of large body phenotype of Ilp2^Scer\UAS.cBa/Ilp2^Scer\UAS.cBa, Scer\GAL4^hs.PB (Brogiolo et al., 2001) InR³⁰⁴ is a suppressor of visible phenotype of Ilp2^Scer\UAS.cBa/Ilp2^Scer\UAS.cBa, Scer\GAL4^hs.PB (Brogiolo et al., 2001)
Other
Statement Reference InR^93Dj-4/InR³⁰⁴, Pten^2L100/Pten¹¹⁷ has lethal \| pupal stage phenotype (Oldham et al., 2002, Oldham et al., 2002) InR³²⁷/InR³⁰⁴, Pten^2L100/Pten¹¹⁷ has lethal \| pupal stage phenotype (Oldham et al., 2002, Oldham et al., 2002)
Phenotype Manifest In
Suppressed by
Statement Reference InR³⁰⁴ has head capsule \| somatic clone phenotype, suppressible \| partially by foxo²⁵ (Junger et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	DInr³⁰⁴ (Junger et al., 2003) Inr³⁰⁴ (Clancy et al., 2001) InR³⁰⁴
Name Synonym
Secondary FlyBase IDs

References ( 5 )
Research paper	Bateman and McNeill, 2004, Cell 119(1): 87--96 Temporal control of differentiation by the insulin receptor/tor pathway in Drosophila. [FBrf0180028] Junger et al., 2003, J. Biol. 2(3): 20 The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. [FBrf0162177] Oldham et al., 2002, Development 129(17): 4103--4109 The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP₃ levels. [FBrf0151278] Brogiolo et al., 2001, Curr. Biol. 11(4): 213--221 An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. [FBrf0134520] Clancy et al., 2001, Science 292(5514): 104--106 Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. [FBrf0135946]

Allele Dmel\InR304

Allele Dmel\InR³⁰⁴