FlyBase Allele Report: Dmel\14-3-3ζ[P2335]

General Information

Symbol

Dmel\14-3-3ζ^P2335

Species

D. melanogaster

Name

FlyBase ID

FBal0134434

Feature type

allele

Associated gene

Dmel\14-3-3ζ

Associated Insertion(s)

P{unk}14-3-3ζ^P2335

Carried in Construct

Also Known As

leo^P2335

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Philip et al., 2001)

Progenitor genotype

Associated Insertion(s)

P{unk}14-3-3ζ^P2335

Cytology

Description

Insertion, in forward orientation, into the intron between exons 1' and 2 of 14-3-3ζ.

(Philip et al., 2001)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal learning (with 14-3-3ζ^P1188), with 14-3-3ζ^LI.15.hs

(Philip et al., 2001)

abnormal learning (with 14-3-3ζ^P1188), with 14-3-3ζ^LI.15.hs, 14-3-3ζ^LII.2.hs

(Philip et al., 2001)

lethal

(Philip et al., 2001)

lethal (with 14-3-3ζ^P1188)

(Messaritou et al., 2010, Messaritou et al., 2009)

viable (with 14-3-3ζ^P1188), with 14-3-3ζ^LI.15.hs

(Philip et al., 2001)

viable (with 14-3-3ζ^P1188), with 14-3-3ζ^LI.15.hs, 14-3-3ζ^LII.2.hs

(Philip et al., 2001)

Phenotype Manifest In

Detailed Description

Statement

Reference

12-18% of 14-3-3ζ^P1188/14-3-3ζ^P2335 heteroallelic animals are escapers. They do not exhibit external defects or grossly aberrant behaviors, despite no 14-3-3ζ expression.

(Messaritou et al., 2009)

Flies rescued from lethality by 14-3-3ζ^LI.15.hs or 14-3-3ζ^LI.15.hs and 14-3-3ζ^LII.2.hs show a 25-30% decrement in olfactory learning, comparable to that of (rescued) 14-3-3ζ^2.3. The restoration of learning by the transgenes decays back to mutant levels 60-70 hr later.

(Philip et al., 2001)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

14-3-3ζ^P2335/14-3-3ζ^P1188 is rescued by 14-3-3ζ^I.UAS/Scer\GAL4^elav.PLu

(Messaritou et al., 2009)

14-3-3ζ^P2335/14-3-3ζ^P1188 is rescued by 14-3-3ζ^II.UAS/Scer\GAL4^elav.PLu

(Messaritou et al., 2009)

14-3-3ζ^P2335/14-3-3ζ^P1188 is rescued by 14-3-3ζ^{III.UAS.Tag:FLAG}/Scer\GAL4^elav.PLu

(Messaritou et al., 2009)

14-3-3ζ^P2335/14-3-3ζ^P1188 is rescued by 14-3-3ζ^LI.15.hs

(Philip et al., 2001)

14-3-3ζ^P2335/14-3-3ζ^P1375 is rescued by 14-3-3ζ^LI.15.hs

(Philip et al., 2001)

Partially rescued by

14-3-3ζ^P2335/14-3-3ζ^P1188 is partially rescued by Scer\GAL4^elav.PU/14-3-3ζ^{WW.UAS.Tag:FLAG}

(Messaritou et al., 2010)

14-3-3ζ^P2335/14-3-3ζ^P1188 is partially rescued by Scer\GAL4^elav.PU/14-3-3ζ^{MW.UAS.Tag:FLAG}

(Messaritou et al., 2010)

Not rescued by

14-3-3ζ^P2335/14-3-3ζ^P1188 is not rescued by Scer\GAL4^elav.PU/14-3-3ζ^{WM.UAS.Tag:FLAG}

(Messaritou et al., 2010)

14-3-3ζ^P2335/14-3-3ζ^P1188 is not rescued by Scer\GAL4^elav.PU/14-3-3ζ^{MM.UAS.Tag:FLAG}

(Messaritou et al., 2010)

14-3-3ζ^P2335 is not rescued by 14-3-3ζ^LI.15.hs

(Philip et al., 2001)

14-3-3ζ^P2335 is not rescued by 14-3-3ζ^LII.2.hs

(Philip et al., 2001)

Comments

Expression of 14-3-3ζ^{III.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^elav.PLu partially rescues the lethality found in 14-3-3ζ^P1188/14-3-3ζ^P2335 heterozygotes to approximately 70% of expected.

Expression of 14-3-3ζ^II.Scer\UAS under the control of Scer\GAL4^elav.PLu partially rescues the lethality found in 14-3-3ζ^P1188/14-3-3ζ^P2335 heterozygotes to approximately 15-20% of expected.

Expression of 14-3-3ζ^I.Scer\UAS under the control of Scer\GAL4^elav.PLu partially rescues the lethality found in 14-3-3ζ^P1188/14-3-3ζ^P2335 heterozygotes to approximately 20% of expected.

(Messaritou et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

14-3-3ζ^P2335

leo^P2335

(Messaritou et al., 2010, Messaritou et al., 2009, Philip et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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