FB2025_01 , released February 20, 2025
Allele: Dmel\aurA37
Open Close
General Information
Symbol
Dmel\aurA37
Species
D. melanogaster
Name
FlyBase ID
FBal0137332
Feature type
allele
Associated gene
Dmel\aurA
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Berdnik and Knoblich, 2002)
Progenitor genotype
Cytology
Description

Amino acid replacement: R201H. Nucleotide substitution: G?A. The mutation is within the catalytic domain.

(Berdnik and Knoblich, 2002)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:11,964,019..11,964,019 [+]
Nucleotide change:

G11964019A

Amino acid change:

R201H | aurA-PA

Reported amino acid change:

R201H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Berdnik and Knoblich, 2002)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      aur37/aur87Ac-3 larval brain neuroblasts show overproliferation.

      (Wirtz-Peitz et al., 2008)

      Mutant bristles have two sockets and two hairs.

      (Hutterer et al., 2006)

      Homozygous mutant clones can be made in all tissues derived from the eye imaginal disk this includes most of the head cuticle. This leads to morphologically abnormal bristles that contain two hairs and two socket. This is caused by a failure in the asymmetric division of the mutant sensory organ precursor cells. Homozygous mutants, aur37/Df(3R)P-58 and aur37/aur87Ac-3 transheterozygous adults frequently form morphologically abnormal bristles that contain two hairs and two sockets. Bipolar mitotic spindles are formed in aur37 mutant cells, also the minus ends of the microtubules form a less focused pole around the centrosome. Mutants also exhibit defects in centrosome maturation. Spindle orientation however remains normal.

      (Berdnik and Knoblich, 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The overproliferation of larval brain neuroblasts seen in aur37/aur87Ac-3 animals is suppressed by expression of bazScer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL41407.

      Expression of l(2)glScer\UAS.cBa under the control of Scer\GAL41407 in aur37/aur37 mutants results in neuroblast overproliferation in the larval brain.

      (Wirtz-Peitz et al., 2008)

      The duplication of sockets and hairs seen in mutant external sensory organs in aur37 mutants can be suppressed by expression of boraScer\UAS.T:Avic\GFP-S65T under the control of Scer\GAL4sca-109-68.

      (Hutterer et al., 2006)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      aurA87Ac-3

      (Berdnik and Knoblich, 2002)
      Comments

      aur37/aur87Ac-3 is a lethal combination.

      (Berdnik and Knoblich, 2002)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AurA37
      (Carvalho et al., 2015)
      aur37
      (Carvalho et al., 2015)
      aurA37
      (Wirtz-Peitz et al., 2008, Wirtz-Peitz et al., 2008, Hutterer et al., 2006, Berdnik and Knoblich, 2002)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)