FlyBase Allele Report: Dmel\Liprin-α[R117]

General Information

Symbol

Dmel\Liprin-α^R117

Species

D. melanogaster

Name

FlyBase ID

FBal0137467

Feature type

allele

Associated gene

Dmel\Liprin-α

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Kaufmann et al., 2002)

Progenitor genotype

P{EP}homer^EP2141

(Kaufmann et al., 2002)

Caused by aberration

Df(2L)Liprin-α^R117

Cytology

Description

Imprecise excision of P{EP}EP2141, removing most of the upstream region of Liprin-α.

(Kaufmann et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy (with Liprin-α^1J-0)

(Kaufmann et al., 2002)

abnormal neurophysiology (with Liprin-α^F3ex15)

(Kaufmann et al., 2002)

Phenotype Manifest In

bouton (with Liprin-α^1J-0)

(Kaufmann et al., 2002)

neuromuscular junction (with Liprin-α^1J-0)

(Kaufmann et al., 2002)

neuromuscular junction (with Liprin-α^F3ex15)

(Kaufmann et al., 2002)

Detailed Description

Statement

Reference

Liprin-α^1J-0/Liprin-α^R117 larvae have fewer boutons (both type Ib and type Is) at the muscle 6/7 neuromuscular junction than wild type. The branch complexity of the terminal arbor is also decreased compared to wild type. Liprin-α^1J-0/Liprin-α^R117 larval neuromuscular junctions frequently lack small nascent boutons ("buds") surrounding a large end bouton (which are seen in wild-type animals). Excitatory junctional potentials (EJPs) are reduced 36% in Liprin-α^F3ex15/Liprin-α^R117 larvae compared to controls. The mean amplitude and the frequency of unitary mRJPs is normal. The resting potential of the muscle is normal. The quantal content of evoked release is reduced by over 50%.

(Kaufmann et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Liprin-α^1J-0/Liprin-α^R117 has bouton phenotype, non-suppressible by Lar^UAS.cKa/Scer\GAL4^elav.PLu

(Kaufmann et al., 2002)

Suppressor of

Statement

Reference

Liprin-α^1J-0/Liprin-α^R117 is a suppressor of bouton | increased number phenotype of Lar^UAS.cKa, Scer\GAL4^elav.PLu

(Kaufmann et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Liprin-α^1J-0/Liprin-α^R117 larvae expressing Lar^Scer\UAS.cKa under the control of Scer\GAL4^elav.PLu show a reduction in bouton number at the muscle 6/7 neuromuscular junction equivalent to that seen in Liprin-α^1J-0/Liprin-α^R117 single mutants.

(Kaufmann et al., 2002)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Liprin-α^EPexR117

(Kaufmann et al., 2002)

Liprin-α^R117

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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