Allele Dmel\Liprin-α^R117

General Information
Symbol	Dmel\Liprin-α^R117	Species	D. melanogaster
Name		FlyBase ID	FBal0137467
Feature type	allele	Associated gene	Dmel\Liprin-α

Allele class
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Kaufmann et al., 2002)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EP}homer^EP2141 (Kaufmann et al., 2002)
Nature of the lesion	Statement Reference Imprecise excision of P{EP}EP2141, removing most of the upstream region of Liprin-α. (Kaufmann et al., 2002)
Caused by aberration	Df(2L)Liprin-α^R117 (Kaufmann et al., 2002)
Cytology
Phenotypic Data
Phenotypic Class
	neuroanatomy defective (with Liprin-α^1J-0) (Kaufmann et al., 2002) neurophysiology defective (with Liprin-α^F3ex15) (Kaufmann et al., 2002)
Phenotype Manifest In
	bouton (with Liprin-α^1J-0) (Kaufmann et al., 2002) neuromuscular junction (with Liprin-α^1J-0) (Kaufmann et al., 2002) neuromuscular junction (with Liprin-α^F3ex15) (Kaufmann et al., 2002)
Detailed Description
	Statement Reference Liprin-α^1J-0/Liprin-α^R117 larvae have fewer boutons (both type Ib and type Is) at the muscle 6/7 neuromuscular junction than wild type. The branch complexity of the terminal arbor is also decreased compared to wild type. Liprin-α^1J-0/Liprin-α^R117 larval neuromuscular junctions frequently lack small nascent boutons ("buds") surrounding a large end bouton (which are seen in wild-type animals). Excitatory junctional potentials (EJPs) are reduced 36% in Liprin-α^F3ex15/Liprin-α^R117 larvae compared to controls. The mean amplitude and the frequency of unitary mRJPs is normal. The resting potential of the muscle is normal. The quantal content of evoked release is reduced by over 50%. (Kaufmann et al., 2002)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
NOT suppressed by
Statement Reference Liprin-α^1J-0/Liprin-α^R117 has bouton phenotype, non-suppressible by Lar^Scer\UAS.cKa/Scer\GAL4^elav.PLu (Kaufmann et al., 2002)
Suppressor of
Statement Reference Liprin-α^1J-0/Liprin-α^R117 is a suppressor of bouton \| supernumerary phenotype of Lar^Scer\UAS.cKa, Scer\GAL4^elav.PLu (Kaufmann et al., 2002)
Additional Comments
Genetic Interactions
Statement Reference Liprin-α^1J-0/Liprin-α^R117 larvae expressing Lar^Scer\UAS.cKa under the control of Scer\GAL4^elav.PLu show a reduction in bouton number at the muscle 6/7 neuromuscular junction equivalent to that seen in Liprin-α^1J-0/Liprin-α^R117 single mutants. (Kaufmann et al., 2002)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Liprin-α^EPexR117 (Kaufmann et al., 2002) Liprin-α^R117
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Kaufmann et al., 2002, Neuron 34(1): 27--38 Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. [FBrf0147174]

Allele Dmel\Liprin-αR117

Allele Dmel\Liprin-α^R117