FB2025_01 , released February 20, 2025
Allele: Dmel\kibraUAS.cBa
Open Close
General Information
Symbol
Dmel\kibraUAS.cBa
Species
D. melanogaster
Name
FlyBase ID
FBal0244823
Feature type
allele
Associated gene
Dmel\kibra
Associated Insertion(s)
Carried in Construct
P{UAS-kibra.B}
Also Known As
UAS-Kibra
Key Links
Transgenic product class
wild_type
(Baumgartner et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Baumgartner et al., 2010)
Mutagen
in vitro construct
(Baumgartner et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-kibra.B}
Cytology
Description

UAS regulatory sequences drive expression of kibra.

(Baumgartner et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
kibra
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of kibraScer\UAS.cBa driven by Scer\GAL4futsch-C380 (along with Scer\GAL80ChAT.3.3P) does not significantly affect dendritic branch length or number in MN5 motoneurons, though there are subtle changes in branch patterning.

      (Williams et al., 2016)

      Clones in the wing disc expressing kibraScer\UAS.cBa under the control of Scer\GAL4Act5C.PP are reduced in size (due to a reduction in the number of cells) compared to control clones.

      Clones in the wing disc expressing kibraScer\UAS.cBa under the control of Scer\GAL4Act5C.Switch.PR in the presence of RU486 show increased programmed cell death compared to controls.

      Expression of kibraScer\UAS.cBa under the control of Scer\GAL4ey.PH results in a small eye phenotype.

      (Baumgartner et al., 2010)

      Expression of kibraScer\UAS.cBa under the control of Scer\GAL4GMR.PF results in a reduced eye.

      (Baumgartner et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      NOT Suppressor of
      Statement
      Reference

      kibraUAS.cBa/Scer\GAL4GMR.PF is a non-suppressor of eye | somatic clone phenotype of sav1X1

      (Baumgartner et al., 2010)

      kibraUAS.cBa/Scer\GAL4GMR.PF is a non-suppressor of eye | somatic clone phenotype of wts5Y2

      (Baumgartner et al., 2010)

      kibraUAS.cBa/Scer\GAL4GMR.PF is a non-suppressor of eye | somatic clone phenotype of Mer4

      (Baumgartner et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye phenotype caused by expression of kibraScer\UAS.cBa under the control of Scer\GAL4ey.PH is partially rescued by co-expression of either thEP3723 or CycEScer\UAS.cLa. Simultaneous co-expression of both thEP3723 and CycEScer\UAS.cLa almost completely rescues the small eye phenotype caused by expression of kibraScer\UAS.cBa under the control of Scer\GAL4ey.PH.

      The eye overgrowth phenotype of eyes homozygous for sav1X1 (generated by the eyFLP method) is not altered by expression of kibraScer\UAS.cBa under the control of Scer\GAL4GMR.PF.

      The eye overgrowth phenotype of eyes homozygous for wts5Y2 (generated by the eyFLP method) is not altered by expression of kibraScer\UAS.cBa under the control of Scer\GAL4GMR.PF.

      (Baumgartner et al., 2010)

      Animals co-expressing both kibraScer\UAS.cBa and ykiScer\UAS.cHa under the control of Scer\GAL4GMR.PF show the same eye overgrowth phenotype as animals expressing ykiScer\UAS.cHa alone under the control of Scer\GAL4GMR.PF.

      (Baumgartner et al., 2010)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      kibraUAS.cBa rescues kibra4

      (Baumgartner et al., 2010)
      Comments

      kibraScer\UAS.cBa rescues the lethality of kibra4 homozygotes in the absence of a Scer\GAL4 driver.

      (Baumgartner et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      kibraScer\UAS.cBa
      kibraUAS.cBa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)