FlyBase Allele Report: Dmel\InR[JF01482]

General Information

Symbol

Dmel\InR^JF01482

Species

D. melanogaster

Name

FlyBase ID

FBal0245746

Feature type

allele

Associated gene

Dmel\InR

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01482}

Also Known As

UAS-InR-RNAi, InR RNAi, UAS-InR^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.JF01482}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01482

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of diabetic neuropathy

CEA

(Wang et al., 2023)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates cancer

modeled by Ras85D^V12.GMR

(Okada et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal immune response, with Scer\GAL4^Act5C.PI

(Ahlers et al., 2019)

abnormal pain response | larval stage, with Scer\GAL4^109(2)80

(Wang et al., 2023)

increased mortality | conditional, with Scer\GAL4^Act5C.PI

(Ahlers et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expresion of InR^JF01482 under the control of Scer\GAL4^Act5C.PI leads to increased mortality as a result of WNV-Kun infection when compared to controls.

(Ahlers et al., 2019)

Mid-third instar larvae expressing InR^JF01482 in the fat body in the fat body under the control of Scer\GAL4^DcG exhibit moderately increased haemolymph glucose levels.

Mid-third instar larvae expressing InR^JF01482 in muscle under the control of Scer\GAL4^Mef2.PU exhibit moderately increased haemolymph glucose levels.

(Ugrankar et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^Cg.PA/InR^JF01482 is a suppressor of increased mortality during development phenotype of Ras85D^V12.GMR

(Okada et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

31037

y¹ v¹; P{TRiP.JF01482}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

InR-JF01482

(Hartman et al., 2013)

InR^JF01482

(Wang et al., 2023, Im et al., 2018)

InR^RNAiJF01482

(Hartman et al., 2013)

Name Synonyms

Secondary FlyBase IDs

References (16)

Report Sections

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