FB2025_01 , released February 20, 2025
Allele: Dmel\Hsp22GD8704
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General Information
Symbol
Dmel\Hsp22GD8704
Species
D. melanogaster
Name
FlyBase ID
FBal0263517
Feature type
allele
Associated gene
Dmel\Hsp22
Associated Insertion(s)
Carried in Construct
P{GD8704}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Chen et al., 2012)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Chen et al., 2012)
Mutagen
in vitro construct
(Chen et al., 2012)
Progenitor genotype
Carried in construct
P{GD8704}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Chen et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD8704
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies expressing Hsp22GD8704 under the control of Scer\GAL4GMR.PU show no defects in ommatidial structure.

      (Chen et al., 2012)

      Short-term recovery from chilling at 0[o]C is significantly affected in Scer\GAL4Act5C.PI/Hsp22GD8704 flies. After 60 minutes, all Scer\GAL4Act5C.PI/+ flies recover, while 24% of Scer\GAL4Act5C.PI/Hsp22GD8704 flies remain in a chill coma. All flies eventually recover and no mortality is observed.

      Medium-term chill-recovery tests reveal significant differences in mobility (climbing) between Scer\GAL4Act5C.PI/+ and Scer\GAL4Act5C.PI/Hsp22GD8704 flies. Differences are manifested after 2 hours and 4 hours of recovery, with, respectively, 74% and 40% f flies still injured in Hsp22GD8704-expressing flies with 52% and 15% in Scer\GAL4Act5C.PI heterozygotes.

      (Colinet et al., 2010)

      Adults expressing Hsp22GD8704 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsp22GD8704
      Name Synonyms
      Secondary FlyBase IDs
        References (6)