FlyBase Allele Report: Dmel\AMPKα[HMC04979]

General Information

Symbol

Dmel\AMPKα^HMC04979

Species

D. melanogaster

Name

FlyBase ID

FBal0300308

Feature type

allele

Associated gene

Dmel\AMPKα

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC04979}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC04979}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC04979

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates carcinoma

modeled by Lkb1^4A4-2, Ras85D^V12.UAS

(Rackley et al., 2021)

exacerbates congenital muscular dystrophy due to LMNA mutation

modeled by LamC^G489V.UAS

(Chandran et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased efficacy of memory | adult stage | calorie restriction conditional, with Scer\GAL4^GMR54H02

(Silva et al., 2022)

decreased rate of flight behavior, with Scer\GAL4^Act88F.PB

(Livelo et al., 2023)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Detailed Description

Statement

Reference

Adults expressing AMPKα^HMC04979 for 2 days under the combined control of Scer\GAL4^GMR54H02 and Gal80[ts] (for temporal control of expression) exhibit decreased olfactory memory under starvation conditions, but not when fed.

(Silva et al., 2022)

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in glossy and necrotic eye phenotype.

(Pletcher et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

AMPKα^HMC04979, Scer\GAL4^fln.IFM is a non-suppressor of flightless | progressive phenotype of LamC^R205W.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

AMPKα^HMC04979, Scer\GAL4^fln.IFM is a non-suppressor of flightless | progressive phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

Phenotype Manifest In

Enhancer of

Statement

Reference

AMPKα^HMC04979, Scer\GAL4^fln.IFM is an enhancer of indirect flight muscle cell | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

AMPKα^HMC04979, Scer\GAL4^fln.IFM is an enhancer of nuclear envelope | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

AMPKα^HMC04979, Scer\GAL4^fln.IFM is an enhancer of nucleus | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

AMPKα^HMC04979, Scer\GAL4^fln.IFM is an enhancer of myofibril | adult stage phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

NOT Suppressor of

Statement

Reference

AMPKα^HMC04979, Scer\GAL4^fln.IFM is a non-suppressor of indirect flight muscle cell | adult stage phenotype of LamC^R205W.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

AMPKα^HMC04979, Scer\GAL4^fln.IFM is a non-suppressor of wing phenotype of LamC^G489V.UAS, Scer\GAL4^fln.IFM

(Chandran et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of LamC^UAS.cSa and AMPKα^HMC04979 under the control of Scer\GAL4^fln.IFM does not lead to any obvious indirect flight muscle, wing posture or flight defects.

(Chandran et al., 2019)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

57785

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04979}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

AMPKα^HMC04979

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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