FlyBase Allele Report: Dmel\tkv[CA.UAS.cUa]

General Information

Symbol

Dmel\tkv^CA.UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0344205

Feature type

allele

Associated gene

Dmel\tkv

Associated Insertion(s)

Carried in Construct

P{UAS-tkv.CA.U}

Also Known As

UAS-tkv^Act, tkv^CA

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Veverytsa and Allan, 2011)

Progenitor genotype

Carried in construct

P{UAS-tkv.CA.U}

Cytology

Description

UAS regulatory sequences drive expression of a constitutively activated form of tkv.

(Veverytsa and Allan, 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

tkv

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell number | embryonic stage, with Scer\GAL4^how-24B

(Yang and Su, 2011)

increased cell death | embryonic stage, with Scer\GAL4^how-24B

(Yang and Su, 2011)

Phenotype Manifest In

embryonic cardioblast, with Scer\GAL4^how-24B

(Yang and Su, 2011)

embryonic myoblast, with Scer\GAL4^how-24B

(Yang and Su, 2011)

embryonic pericardial cell, with Scer\GAL4^how-24B

(Yang and Su, 2011)

Detailed Description

Statement

Reference

Adulthood-only expression of tkv^CA.UAS.cUa under the combined control of Scer\GAL4^esg.PU and Gal80[ts] (induced by temperature shift from 18[o]C to 29[o]C) does not affect the number of intestinal progenitors (i.e. esg-positive cells) nor the mitotic index (pH3-positive cells) in the adult posterior midgut, as compared to controls.

(Ma et al., 2019)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

tkv^CA.UAS.cUa/Scer\GAL4^esg.PU is a suppressor of increased cell number | adult stage phenotype of Scer\GAL4^esg.PU, sfl^HMS00543

(Ma et al., 2019)

tkv^CA.UAS.cUa/Scer\GAL4^esg.PU is a suppressor of increased occurrence of cell division | adult stage phenotype of Scer\GAL4^esg.PU, sfl^HMS00543