Reference Report

Reference
Citation	Davis, M.B., MacIntyre, R.J. (1988). A genetic analysis of the α-glycerophosphate oxidase locus in Drosophila melanogaster. Genetics 120(): 755--766. (Export to RIS)
FlyBase ID	FBrf0048246
Publication Type	Research paper
PubMed ID	3147213
PubMed Abstract	The gene for alpha-glycerophosphate oxidase, the nuclear encoded mitochondrial enzyme of the alpha-glycerophosphate cycle (alpha GP); has been mapped in Drosophila melanogaster. Several interstitial deficiencies in region 50c-53AB of chromosome 2R were used to localize the structural gene to 52D2-5. In addition, mutations of alpha GPO were generated; alpha GPO mutants are viable yet flightless. Interactions of alpha GPO with alpha-glycerophosphate dehydrogenase (alpha GPDH), the cytoplasmic enzyme of the alpha GP cycle, were investigated through the synthesis of a series of alpha GPDHnull-alpha GPOnull double mutants. Of the six double null mutants constructed, four alpha GPDH-alpha GPO double nulls are viable and flightless. Two double mutants, however, exhibit an allelic-dependent synthetic lethal phenotype.
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (18)
	Df(2L)cl7 Df(2R)KL9 Df(2R)KL32 Df(2R)KL69 Df(2R)KL99 Df(2R)L4 Df(2R)L7 Df(2R)l30 Df(2R)L48 Df(2R)sf-49 Df(2R)WMG Df(2R)XTE-11 Df(2R)XTE-18 T(Y;2)L110 T(Y;2)R14 Tp(1;2)TE51D Ts(YLt;2Lt)R14+Ts(YSt;2Rt)L110 Ts(YSt;2Rt)R14+Ts(YLt;2Lt)L110
Alleles (17)
	c³ c⁴ c⁵ c⁶ c⁷ Gpdh^n5-4 Gpdh^nRZ1 Gpdh^nSP2 Gpdh^nSP4 Gpdh^nSP8 Gpdh^nSP10 Gpdh^nSP12 Gpo-1ⁿ³¹⁸ Gpo-1ⁿ³²² Gpo-1ⁿ³³² L² nw^B
Genes (18)
	c cl Gpdh Gpo-1 L l(2)52ACa l(2)52ACb l(2)52ACc l(2)52ACd l(2)52ACe l(2)52ACf l(2)52ACg l(2)52ACh l(2)52Da l(2)52Db l(2)52Dc l(2)52Ea nw