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| Citation | Kirienko, N.V., Fay, D.S. (2010). SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network. EMBO J. 29(4): 727--739. (Export to RIS) | ||
| FlyBase ID | FBrf0210031 | ||
| Publication Type | Research paper | ||
| PubMed ID | 20057358 | ||
| PubMed Abstract | Maintaining a homeostatic interaction with the environment is crucial for the growth, survival, and propagation of all living organisms. Reestablishment of equilibrium after stress is achieved by the activation of complex transcriptional-response networks, many of which remain poorly understood. Here, we report that the zinc-finger protein, SLR-2, is a master stress regulator and is required for the normal response to pleiotropic stress conditions in Caenorhabditis elegans. Using bioinformatical tools, we identified an evolutionarily conserved nucleotide motif present in slr-2 stress-responsive genes and show that this motif is sufficient for stress induction under a variety of conditions. We also demonstrate that JMJC-1, a conserved Jumonji C domain protein, acts downstream of SLR-2 to mediate stress response in C. elegans. Moreover, the role of JMJC-1 in stress response is conserved in Drosophila and mammals. Finally, we provide evidence that the SLR-2-JMJC-1 pathway functions independently of the well-studied DAF-16/FOXO1 network. These findings point to a previously unrecognized phylogenetically conserved master stress-response pathway in metazoa. | ||
| DOI | 10.1038/emboj.2009.387 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | EMBO J. | ||
| Title | The EMBO Journal | ||
| Publication Year | 1982- | ||
| ISBN/ISSN | 0261-4189 | ||
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Data from Reference
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| Alleles (1)
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| Genes (10)
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| Insertions (1)
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