FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Aberration: Dmel\Dp(3;3)Tpl
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General Information
Symbol
Dp(3;3)Tpl
Species
D. melanogaster
Name
Duplication (3;3) Triplolethal
FlyBase ID
FBab0003807
Feature type
intrachromosomal_duplication
Also Known As
Dp(3;3)21l73
Computed Breakpoints include

83E1;84B3

Features within 83E1--84B3
Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
C(1)RM
T(Y;3)A109
(Denell, 1976)
T(Y;3)L132
(Denell, 1976)
Mutagen
gamma ray
(Denell, 1976)
Class of aberration (relative to wild type)
intrachromosomal_duplication
Class of aberration (relative to progenitor)
unoriented_insertional_duplication
Breakpoints

83E;84C

(Denell, 1976)

83E;84B

(Dorer et al., 1993, Dorer et al., 1990)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

bk1 << Tpl << bk2

Genetic mapping information
Comments
Comments on Cytology

Ref: Denell, 1976, Genetics 84: 193--210

(Dorer et al., 1993)

Tandem reversed duplication of chromosome bands 83E-84B.

(Dorer et al., 1990)

Reverse duplication of chromosome region 83E-84C.

(Denell, 1976)

Left limit of break 1 from polytene analysis (FBrf0028747) Right limit of break 1 from inclusion of Tpl (citation unavailable) Limits of break 2 from polytene analysis (citation unavailable)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Tpl
(Smoyer et al., 2003, Nelson and Christensen, 1996)
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
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    Phenotypic Data
    In combination with other aberrations

    Su(Tpl)10/Dp(3;3)Tpl larvae survive to adulthood in hyperoxia. These larvae also exhibit a dramatic decrease in the visible tracheal and midgut browning phenotypes and a reduction in cell death in the midgut.

    (Smoyer et al., 2003)
    NOT in combination with other aberrations

    Dp(3;3)Tpl heterozygous flies (carrying three copies of Tpl) die in the first instar larvae stage. Before death, the midgut turns brown (and is the first tissue to die), and tracheal development is abnormal. This is accompanied by more widespread cell death, and then the tracheae appear to break up and turn brown. Soon thereafter, the entire animal dies. These flies are also developmentally-retarded (they exhibit the first-instar phenotype at a time when the wild-type would have already moulted to the second instar stage).

    (Smoyer et al., 2003)

    dominant lethal viable and reasonably fertile over Tpl-- 3. Cell lethal in four doses (Roehrdanz and Lucchesi, 1980).

    Stocks (2)
    Notes on Origin
    Discoverer
     
    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     

    Su(Tpl)10 entirely eliminates the abnormalities and death caused by Tpl trisomy (such as Dp(3;3)Tpl or Dp(3;3)TplJE19 flies), and results in viable, fertile adults.

    (Smoyer et al., 2003)

    Treatment of Ts(YLt;3Lt)A109+Ts(YLt;3Rt)L132/Dp(3;3)Tpl males with ethyl methanesulfonate produced three duplication chromosomes <up>Dp(3;3)9k75-1, Dp(3;3)9k75-2, and Dp(3;3)19k75</up> that are viable over normal 3's, but cytologically show the reversed repeat associated with Dp(3;3)Tpl (Keppy and Denell, 1979).

    Synonyms and Secondary IDs (9)
    Reported As
    Symbol Synonym
    Df(3R)21l73
    (Keppy and Denell, 1979)
    Dp(3)Tpl
    (Christensen and Lucchesi, 1988)
    Dp(3;3)21l73
    (Dorer and Christensen, 1990, Dorer et al., 1990)
    Dp(3;3)83D-E
    Dp(3;3)E6
    Dp(3;3)Tpl
    Dp(3;3)Tpl21
    (Dorer et al., 1993)
    Dp(3R)E6
    (Denell, 1976)
    Name Synonyms
    Duplication (3;3) Triplolethal
    Secondary FlyBase IDs
      References (11)