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Citation
Dorer, D.R., Christensen, A.C., Johnson, D.H. (1990). A novel RNA helicase gene tightly linked to the Triplo-lethal locus of Drosophila.  Nucleic Acids Res. 18(): 5489--5494.
FlyBase ID
FBrf0052735
Publication Type
Research paper
Abstract

The Triplo-lethal (Tpl) locus of Drosophila is the only known locus which is lethal when present in three copies rather than the normal two. After recovering a hybrid-dysgenesis-induced mutation of Tpl we used a rapid combination of transposon tagging, chromosome microdissection and PCR to clone the P element that had transposed into the Tpl region. That P element is located within the gene for a new and unique member of the RNA helicase family. This new helicase differs from all others known by having glycine-rich repeats at both the amino and carboxyl termini. Curiously, genetic analysis shows that the P element inserted into this gene is not responsible for the Tpl mutant phenotype. We present possible explanations for these findings.

PubMed ID
PubMed Central ID
PMC332228 (PMC) (EuropePMC)
Associated Information
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Nucleic Acids Res.
    Title
    Nucleic Acids Research
    Publication Year
    1974-
    ISBN/ISSN
    0305-1048
    Data From Reference
    Aberrations (1)
    Alleles (3)
    Genes (5)
    Insertions (1)