FB2025_02 , released April 17, 2025
Aberration: Dmel\In(1)sc4
Open Close
General Information
Symbol
In(1)sc4
Species
D. melanogaster
Name
Inversion (1) scute
FlyBase ID
FBab0004187
Feature type
chromosomal_inversion
Also Known As
sc4
Computed Breakpoints include

1B3;h26-h28

Sequence coordinates
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
Mutagen
X ray
Class of aberration (relative to wild type)
chromosomal_inversion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_inversion
(Belyaeva et al., 1998, Lindsley and Grell, 1968)
Breakpoints

1B3-1B4;19F-20C1

(Lindsley and Grell, 1968)

1B3-1B4;h26-h28

(Belyaeva et al., 1998)
Causes alleles
AO-X1
(Malva et al., 1985)
sc4
(Gomez-Skarmeta et al., 1995, Campuzano and Modolell, 1992, Cubas et al., 1991, Romani et al., 1989, Campuzano et al., 1985, Malva et al., 1985)
Carries alleles
y1
Nopa31
(Rice et al., 2015)
Transposon Insertions
Formalized genetic data

Zhr << bk1 << l(1)sc << bk2 hits ABO-X

Genetic mapping information
Comments

Breakpoint(s) molecularly mapped

(Ruiz-Gomez and Ghysen, 1993, Campuzano et al., 1985, Carramolino et al., 1982)

Left breakpoint between DNA coordinates +24.0 and +25.8 (Campuzano et al., 1985). 0 is an arbitrarily chosen EcoRI site in the scĪ² segment of ASC; positive values to the left (Carramolino, Ruiz-Gomez, Guererro, Campuzano and Modolell, 1982, EMBO J. 1: 1185-92).

Comments on Cytology

The proximal breakpoint is in or near the ABO-X heterochromatic region that maternally interacts with the abo gene product.

(Malva et al., 1985)

Left limit of break 1 from polytene analysis (FBrf0042024) Right limit of break 1 from complementation mapping against l(1)sc (FBrf0047940) Left limit of break 2 from complementation mapping against ABO-X (FBrf0042645) Right limit of break 2 from polytene analysis (FBrf0105072)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
sc
(Campuzano and Modolell, 1992, Campuzano et al., 1985)
Partially deleted / disrupted
Molecular Data
Completely deleted
Partially deleted
Genes NOT Deleted / Disrupted
Complementation Data
 
pad
(Gibert et al., 2005)
Molecular Data
 
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location (0)
    If no genes are listed here, it may be because the affected region is very large. The JBrowse insert above may show an error for the same reason, and other FlyBase tools such as CytoSearch may also fail for large regions. You can contact FlyBase for more help.
    In these cases, there will be no "Export to Hitlist" button to the left.
    Phenotypic Data
    In combination with other aberrations
    NOT in combination with other aberrations

    In(1)sc4 causes a loss of all scutellar bristles.

    (Gibert et al., 2005)

    Homozygous females show a loss of tergite chaetae.

    (Mari-Beffa et al., 1991)

    Maternal and zygotic interactions between abo and In(1)sc4 (Malva, Labella, Manzi, Salzano, Lavorgna, De Ponti and Graziani, 1985, Genetics 111: 487-94). In(1)sc4/+ female produces about 6% exceptional males from 4-strand double exchange. Secondary exceptions about 4%.

    Stocks (2)
    Notes on Origin
    Discoverer

    Agol, 1928.

     

    on a y chromosome

    Balancer / Genotype Variants of the Aberration
     
    Separable Components
     
    Other Comments
     
    Synonyms and Secondary IDs (4)
    Reported As
    Symbol Synonym
    In(1)sc4
    (Kolesnikova et al., 2001)
    In(1)sc4
    (Rice et al., 2015, Demakova et al., 2007)
    sc4
    (Park and Yamamoto, 1995, Mari-Beffa et al., 1991, Leyns et al., 1989)
    Name Synonyms
    Inversion (1) scute
    Secondary FlyBase IDs
      References (37)