FlyBase Aberration Report: Dmel\Df(2R)ED2238

General Information

Symbol

Df(2R)ED2238

Species

D. melanogaster

Name

FlyBase ID

FBab0033533

Feature type

chromosomal_deletion

Computed Breakpoints include

[47F13-47F13];[48C5-48C5];

Features within 47F13--48C5

Genomic Maps

JBrowse

Sequence coordinates

2R:11,452,980..11,452,980 (Df(2R)ED2238:bk1)

(DrosDel Project, 2007.6.25)

2R:11,892,107..11,892,107 (Df(2R)ED2238:bk2)

(DrosDel Project, 2007.6.25)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

P{RS3r}CB-6286-3

(Gryzik and Muller, 2004)

P{RS5r}5-HA-1544

(Gryzik and Muller, 2004)

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Gryzik and Muller, 2004, Ryder, 2003.6.17)

Breakpoints

47F13;48C5

(FlyBase Curators, 2008)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

Genetic mapping information

Comments

Comments on Cytology

Limits of break 1 computationally determined from location of progenitor P insertion on genome sequence between P{lacW}Tapδ^k17005&P{lacW}k05103 and P{lacW}l(2)k13403^k13403&P{lacW}Egm^k14708 Limits of break 2 computationally determined from location of progenitor P insertion on genome sequence between P{lacW}Ef1α48D^k17014 and P{lacW}l(2)k06612^k06612

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location (46)

Related Comments

Phenotypic Data

In combination with other aberrations

NOT in combination with other aberrations

The mesoderm is not aligned along the midline in homozygous embryos after invagination and ectoderm-mesoderm adhesion is severely disturbed. Subsequently, the mesoderm cells fail to spread dorsally.

Cells at the dorsal edge of the mesoderm form only short filopodial protrusions during dorsolateral migration in homozygous embryos, in contrast to wild-type cells which form thin, long protrusions.

The number of cardiac muscle precursors is strongly reduced in homozygous embryos at stage 13/14 and at stage 16.

(Klingseisen et al., 2009)

Mesoderm cells do not spread out in homozygous embryos at the time when mesoderm migration normally occurs but remain associated with each other. At later stages, there is a failure to produce dorsal mesoderm derivatives.

(Gryzik and Muller, 2004)

Stocks (0)

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Df(2R)2238

(Klingseisen et al., 2009)

Df(2R)ED2238

(Wu et al., 2017, Klingseisen et al., 2009, FlyBase Curators, 2008)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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