FGF8-like2
FGFs involved in mesodermal development - ligands for Heartless - Thisbe, released from olfactory neurons, particularly from local interneurons, instructs ensheathing glia to wrap each glomerulus
Please see the JBrowse view of Dmel\pyr for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\pyr using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: broad lateral stripes
Comment: in the dorsal-most cells of the germ band
Comment: distinct from ths expression
In stage 10 embryos, pyr expression is limited to the ventral midline neuronal lineage and the dorsal ectoderm region.
pyr is expressed in the cells that serve as substrate for mesoderm cells during migration.
In stage 10 embryos, pyr expression is limited to the ventral midline neuronal lineage and the dorsal ectoderm region.
JBrowse - Visual display of RNA-Seq signals
View Dmel\pyr in JBrowse2-65
2-65.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
pyr and ths show redundancy in the process of mesoderm spreading during gastrulation. pyr is required for formation of cellular protrusions during dorsolateral migration of the mesoderm and for differentiation of pericardial and cardioblast lineages. Other mesodermal lineages, however, require both ths and pyr for their consistent specification.
Loss of function mutants show loss of cardiac tissues and hindgut musculature.
Source for identity of: pyr CG13194
The genes "pyramus" and "thisbe" are named for the "heartbroken" lovers described in Ovid's Metamorphoses because the genes are linked and the mutant phenotype shows a lack of heart.
