[94A2-94A2];[94A6-94A6];
A set of isogenic deficiency stocks created by FLP-induced recombination between FRT-carrying transgenic insertions; molecularly defined deletion endpoints correspond to initial location of the progenitor insertions. Initial set of 519 isogenic deletions provides 56% genome coverage.
The current Exelixis collection at the Bloomington Stock Center differs from the original described in FBrf0175003 : a significant number were shown not to carry a deletion and have been removed from the collection; a number of stocks have been lost; a number of additional deletions are included that were generated after publication.
94A2;94A9
94A2;94A6
Breakpoint based on release 3 sequence coordinate from Parks et al., 2004 (FBrf0174230), converted to release 5 coordinate.
Lethal in combination with Df(3R)BSC637.
Homozygous lethal (homozygotes do not survive to adulthood). Homozygous embryos develop normally until very late embryogenesis. Stage 10 homozygous embryos, and primary cultures made from them, are indistinguishable from wild type.
The proportion of neurons displaying a very fast inactivation, consistent with Shal channels exclusively in a "fast" gating mode, is increased in cultures of neurons derived from homozygous embryos compared to controls.