FlyBase Gene Report: Dmel\CG34377

General Information

Symbol

Dmel\CG34377

Species

D. melanogaster

Name

Annotation Symbol

CG34377

Feature Type

protein_coding_gene

FlyBase ID

FBgn0263117

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

94A4-94A5

Sequence location

3R:22,308,663..22,324,094 [-]

Recombination map

3-74

RefSeq locus

NT_033777 REGION:22308663..22324094

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (1 term)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000266438

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG34377 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A0B4KGJ9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Stop codon suppression postulated at 5' end of gene; upstream AUG translation start utilized.

Gene model reviewed during 5.56

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216885.

Gene model reviewed during 5.55

Gene model reviewed during 6.02

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG34377-RA

FBtr0112610

NM_142761

5273

374

CG34377-RB

FBtr0307884

NM_001260307

5047

374

CG34377-RC

FBtr0330388

NM_001275901

5273

453

CG34377-RD

FBtr0345325

NM_001300532

5288

374

CG34377-RE

FBtr0347067

NM_001316614

5273

385

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG34377-PA

FBpp0111522

42.3

374

9.06

FBpp0300318

42.3

374

9.06

FBpp0303414

49.7

453

9.10

FBpp0311485

42.3

374

9.06

FBpp0312461

43.3

385

8.90

A0A126GV14

NP_001303543

ALI30629

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

374 aa isoforms: CG34377-PA, CG34377-PB, CG34377-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG34377 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34377_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.39

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG34377 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG34377

View exonic expression by tissue for Dmel\CG34377

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42608/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263117

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263117

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG34377

Transgenic constructs containing regulatory region of CG34377

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3R)Exel6190

(Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG34377^c05998

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

viable, with Scer\GAL4^Mef2.PR

viable, with Scer\GAL4^pnr-MD237

viable, with Scer\GAL4^tin.CΔ4

CG34377^GD16744

Sterility

Allele

fertile

CG34377^c05998

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (20)

Hsap\SAMD5

7 of 14

Yes

4 of 14

4 of 14

4 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (19)

Rnor\Samd5

7 of 14

Yes

4 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (21)

Mmus\Samd5

7 of 14

Yes

4 of 14

4 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (11)

Xtro\sash3

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\kiaa1217

1 of 13

Xtro\klhl17

1 of 13

Xtro\samsn1

1 of 13

Danio rerio (Zebrafish) (24)

Drer\sash1b

5 of 14

Yes

4 of 14

3 of 14

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\C46H3.2

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (2)

Agam\AgaP_AGAP004106

4 of 12

Yes

Agam\AgaP_AGAP000961

2 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG34377. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (5)

SKIP

7 of 13

CG17625

5 of 13

ckn

2 of 13

CG4393

1 of 13

CG34384

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SAMD5; sterile alpha motif domain containing 5

7 of 14

620517

SAMSN1; SAM domain, SH3 domain and nuclear localization signals 1

4 of 14

607978

SASH1; SAM and SH3 domain containing 1

4 of 14

607955

dyschromatosis universalis hereditaria

SASH3; SAM and SH3 domain containing 3

4 of 14

300441

IMMUNODEFICIENCY 102; IMD102

immunodeficiency 102

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263117

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene_with_stop_codon_read_through

(Jungreis, 2011.11.18)

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-74

Cytogenetic map

94A4-94A5

Sequence location

3R:22,308,663..22,324,094 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94A4-94A5

Limits computationally determined from genome sequence between P{lacW}how^j5B5&P{EP}EP738 and P{lacW}l(3)L3560^L3560

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-74

(FlyBase, 2016)

3-77.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

93916

y¹ w^*; TI{CRIMIC.TG4.0}CG34377^{CR02537-TG4.0}

13860R-1

13860R-2

v101964

v106556

v318724

PBac{fTRG01019.sfGFP-TVPTBF}VK00002

Genomic Clones (24)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (4)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI20773

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Annotation (CG13858) eliminated in release 5.35 of the genome annotation. Corresponds to 5' UTR of downstream gene.

(FlyBase Genome Annotators, 2011)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG13859 CG13860 CG13861

(FlyBase Genome Annotators, 2007)

Source for merge of: CG34377 CG13858

(FlyBase Genome Annotators, 2011)

Additional comments

Annotation CG13858 (previously withdrawn) merged with annotation CG34377 in release 5.36 of the genome annotation; CG13858 corresponds to 5' UTR of CG34377.

(FlyBase Genome Annotators, 2011)

Annotations CG13859, CG13860 and CG13861 merged as CG34377 in release 5.2 of the genome annotation.

(FlyBase Genome Annotators, 2007)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG13858

(FlyBase Genome Annotators, 2011, Jungreis, 2011.11.18, Keleman et al., 2009.8.5)

CG13859

CG13860

CG13861

CG34377

(Miao et al., 2024, Wang et al., 2024, Slaidina et al., 2021, Gene Disruption Project members, 2018-, Sarov et al., 2016, Ashwal-Fluss et al., 2014, Japanese National Institute of Genetics, 2012.5.21, FlyBase Genome Annotators, 2011, Jungreis, 2011.11.18, Keleman et al., 2009.8.5, FlyBase Genome Annotators, 2007)

Name Synonyms

CG13859

CG13860

CG13861

Secondary FlyBase IDs

FBgn0040585
FBgn0085406
FBgn0038940
FBgn0038939
FBgn0040584

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 37 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42608

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A0B4KGJ9

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A0B4KGJ9

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42608/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0263117

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0263117

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34377

MARRVEL_MODEL - MARRVEL (model organism gene)

42608

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0263117

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG34377_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0263117

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031001

References (32)

The following external sites may use different assemblies or annotations than FlyBase.

-0.39

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