FlyBase Allele Report: Dmel\Antp[Ctx]

General Information

Symbol

Dmel\Antp^Ctx

Species

D. melanogaster

Name

FlyBase ID

FBal0000582

Feature type

allele

Associated gene

Dmel\Antp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

X ray

Nature of the Allele

Allele class

gain of function allele

(Jorgensen and Garber, 1987, Schneuwly et al., 1987)

Mutagen

X ray

(Scott et al., 1983)

Progenitor genotype

Caused by aberration

Tp(3;2)Antp^Ctx

Cytology

Description

Complex rearrangement.

(Schneuwly et al., 1987)

breakpoint is at map position +165-166.

(Scott et al., 1983)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Scott et al., 1983)

viable (with Antp¹)

(Southworth and Kennison, 2002)

viable (with Antp²³)

(Southworth and Kennison, 2002)

visible | dominant

(Schneuwly et al., 1987)

visible | dominant | homeotic

(Jorgensen and Garber, 1987)

Phenotype Manifest In

Detailed Description

Statement

Reference

Antp^Ctx mutants exhibit ectopic wing and thoracic outgrowths on the dorsal rim of the eye, head capsule-to-thorax, and antenna-to-leg transformations, and general eye reduction. The eye disc in Antp^Ctx flies is transformed into different parts of the wing disc, indicating a more general homeotic transformation toward T2.

(Prince et al., 2008)

Transformation of head to thoracic tissue.

(Jorgensen and Garber, 1987)

Posterior dorsal head structures are transformed to dorsal mesothoracic structures.

(Schneuwly et al., 1987)

Occasionally antennae to leg transformation. Dorsal head is transformed to dorsal thoracic tissue.

(Scott et al., 1983)

Strong allele.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Antp^Ctx has wing | ectopic phenotype, enhanceable by ci^D/ci[+]

(Prince et al., 2008)

Antp^Ctx has eye phenotype, enhanceable by ci^D/ci[+]

(Prince et al., 2008)

Antp^Ctx has eye phenotype, enhanceable by bip2[+]/Taf3⁴

(Prince et al., 2008)

Other

Statement

Reference

Antp^Ctx, pb^hs.PB has antenna phenotype

(Cribbs et al., 1995)

Antp^Ctx, pb^hs.PB has maxillary palp | ectopic phenotype

(Cribbs et al., 1995)

Additional Comments

Genetic Interactions

Statement

Reference

Approximately 14% of Antp^Ctx/+;ci^D/+ flies exhibit ectopic wings on the head as compared to 4% in Antp^Ctx/+;bip2⁴/+ transheterozygous flies. Flies showing an ectopic wing on the head almost always show a normal or slightly reduced eye, whereas flies with a head capsule-to-thorax transformation mostly have reduced or lost eyes.

Antp^Ctx/+;bip2⁴/+ flies show stronger eye-reduction/eye-loss phenotypes compared to Antp^Ctx/+;ci^D/+ flies. Ninety percent of the eyes of Antp^Ctx/+;ci^D/+ flies show a normal to weakly reduced eye phenotype, whereas only 34% of the eyes of Antp^Ctx/+;bip2⁴/+ flies show an eye-loss phenotype, compared with 2% without the bip2⁴ mutation.

(Prince et al., 2008)

Homeotic transformation of antennae to T2 leg seen in Antp^Ctx flies can be redirected by pb^hs.PB from ectopic leg to maxillary palp.

(Cribbs et al., 1995)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

2251

Tp(3;2)Antp^Ctx, Antp^Ctx Sb^sbd-2/TM1

Notes on Origin

Discoverer

Lewis.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Antp^Ctx

(Prince et al., 2008)

Ctx

Name Synonyms

AntpCephalothorax

(Prince et al., 2008)

Secondary FlyBase IDs

References (7)

Report Sections

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