FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ten-acbd-KS171
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General Information
Symbol
Dmel\Ten-acbd-KS171
Species
D. melanogaster
Name
FlyBase ID
FBal0001558
Feature type
allele
Associated gene
Dmel\Ten-a
Associated Insertion(s)
Carried in Construct
Also Known As
cbdKS171
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

Amino acid replacement: G1723S.

(Cheng et al., 2013)

Mutation points are assigned to the RE transcript, which encodes the largest protein isoform. GGC codon changed to AGC.

(Cheng et al., 2013)

Nucleotide substitution: G?A.

(Cheng et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:12,318,895..12,318,895 [+]
Nucleotide change:

G12318895A

Reported nucleotide change:

G?A

Amino acid change:

G1349S | Ten-a-PD; G1723S | Ten-a-PE; G1349S | Ten-a-PF; G1247S | Ten-a-PG; G1349S | Ten-a-PI; G1349S | Ten-a-PK; G1358S | Ten-a-PL; G1358S | Ten-a-PM; G1349S | Ten-a-PN; G1732S | Ten-a-PO; G1723S | Ten-a-PP

Reported amino acid change:

G1723S

(Cheng et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes and hemizygotes show a disrupted ellipsoid body and fan-shaped body within the central complex of the brain.

      Transheterozygotes with Ten-a900 show a disrupted ellipsoid body and fan-shaped body within the central complex of the brain.

      Unlike in wild type, the fan-shaped body precursors do not merge at 8-9 APF (or at later time points) in Ten-acbd-KS171 mutants. A Scer\GAL4c767-labeled midline structure, that appears to influence merging in wild type, prematurely detaches from the fan-shaped body precursors in Ten-acbd-KS171 mutants.

      The number and projection tracts of Scer\GAL4NP6510- and Scer\GAL4c205-labelled F1 and F5 neurons are unaffected in Ten-acbd-KS171 mutants, compared to wild type.

      (Cheng et al., 2013)

      Mutants have impaired visual pattern memory.

      (Liu et al., 2006)

      Dramatic abnormality in central body usually with fusion of fan-shaped body and ellipsoid organ; only the protocerebral bridge appears wild type. Abnormal position and internal structure of optic lobes.

      (Strauss and Heisenberg, 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Ten-acbd-KS171 is partially rescued by Scer\GAL4c767/Ten-aUAS.cCa

      (Cheng et al., 2013)
      Comments

      Scer\GAL4c767-mediated expression of Ten-aScer\UAS.cCa partially rescues the the ellipsoid body and fan-shaped body defects of Ten-acbd-KS171 mutants.

      (Cheng et al., 2013)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Ten-acbd-KS171
      cbd2
      cbdKS171
      (Cheng et al., 2013, Liu et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)