FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ccbks145
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General Information
Symbol
Dmel\ccbks145
Species
D. melanogaster
Name
FlyBase ID
FBal0001562
Feature type
allele
Associated gene
Dmel\ccb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Martin-Peña and Ferrus, 2020)
Mutagen
ethyl methanesulfonate
Progenitor genotype
Cytology
Description

The coding region of ccb is intact - the lower expression of ccb in heads from ccbks145 flies indicates that the mutation could affect regulatory regions.

(Martin-Peña and Ferrus, 2020)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Scholz et al., 2000)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      ccbks145 adults exhibit morphological defects in ellipsoid body.

      (Martin-Peña and Ferrus, 2020)

      Show significantly reduced ability to develop ethanol tolerance.

      (Scholz et al., 2000)

      Mutants show defects in the central complex, ranging from failure of the ellipsoid body to close at the ventral aspect to a complete duplication of the ellipsoid body.

      (Renn et al., 1999)

      Fan shaped body and ellipsoid body stretched along the transverse axis, ellipsoid body is opened. Overlaps wild type by approximately 20%. Noduli may be fragments and in 50% of brains protocerebral bridge may be slightly segmented.

      (Strauss and Heisenberg, 1993)

      Ellipsoid body and central body are flat and broadened. Deficient in olfactory learning.

      (Heisenberg et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      ccbks145 has abnormal neuroanatomy | adult stage phenotype, enhanceable by spir[+]/spir1

      (Martin-Peña and Ferrus, 2020)
      Other
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      ccbks145 has ellipsoid body phenotype, enhanceable by spir[+]/spir1

      (Martin-Peña and Ferrus, 2020)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Females display increased ovulation and low receptivity after Acp70A injection.

      (Fleischmann et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      ccb2
      ccbKS145
      (Hong et al., 2008, Renn et al., 1999, Fleischmann et al., 1995, Ferrus and Canal, 1994, Heisenberg et al., 1985)
      ccbks145
      (Martin-Peña and Ferrus, 2020)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)