Chal13 mutants exhibit changes in dendritic arbors in a fraction of MN-DA3 and MN-L1 cells, as compared to wild-type, exhibiting smaller than normal dendritic aborisations in the intermediate neuropile. However, all other motorneurons studied in 18.5 hour Chal13 mutant embryos and innervated territories are comparable to wild-type, indicating that excitatory synaptic input is not essential for the development of normal overall motorneuron dendrite morphology or the formation of the myotopic map.
Df(3R)Cha9/ChATl13 is rescued by ChATm7.4
Df(3R)Cha9/ChATl13 is rescued by ChATm0.8
Df(3R)Cha9/ChATl13 is rescued by ChATm1.2
The order for phenotypic severity for temperature-sensitive paralysis in adults is: Chats3 > Chats2 > Chats1.