FlyBase Allele Report: Dmel\ck[7]

General Information

Symbol

Dmel\ck⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0001687

Feature type

allele

Associated gene

Dmel\ck

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Ashburner et al., 1999.10.12, Gubb et al., 1984)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Gubb et al., 1984)

Description

Amino acid replacement: L1445term.

(Kiehart et al., 2004)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:15,047,903..15,047,903 [-]

Nucleotide change:

T15047903A

Amino acid change:

L1445term | ck-PA; L1445term | ck-PB; L1445term | ck-PC; L1445term | ck-PD

Reported amino acid change:

L1445term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kiehart et al., 2004)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Gubb et al., 1984)

lethal - all die before end of larval stage | recessive

(Kiehart et al., 2004)

partially lethal - majority die | recessive

some die during larval stage | recessive

(Kiehart et al., 2004)

sterile | recessive

(Kiehart et al., 2004)

Phenotype Manifest In

Detailed Description

Statement

Reference

Nearly all homozygotes die as larvae. Mutant escapers are not fertile.

(Kiehart et al., 2004)

Hemizygotes escape lethality with a frequency of 1%-2%.

(Gubb et al., 1984)

Class 2 (survival at >1% <5% expected).

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

ck⁷/ck[+] is a suppressor of visible phenotype of Scer\GAL4^en-e16E, zip^Rod.UAS.GFP

(Franke et al., 2010)

Phenotype Manifest In

Suppressor of

Statement

Reference

ck⁷/ck[+] is a suppressor of wing hair | increased number phenotype of Scer\GAL4^en-e16E, zip^Rod.UAS.GFP

(Franke et al., 2010)

Other

Statement

Reference

ck⁷, wg^l-17 has denticle phenotype

(Bejsovec and Chao, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

ck⁷ modifies the wg^l-17 denticle phenotype, such that the double mutants have denticles with a rounded appearance and no distinctive hook.

(Bejsovec and Chao, 2012)

The multiple wing hair phenotype caused by expression of zip^{Rod.Scer\UAS.T:Avic\GFP} under the control of Scer\GAL4^en-e16E is suppressed by ck⁷/+.

(Franke et al., 2010)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Phenotypic data included in FBrf0051973.

(Roote, 1995.5.4)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

HG32

ck⁷

(Bejsovec and Chao, 2012, Franke et al., 2010)

ck^HG32

(Gubb et al., 1984)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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